Title:
A selection method of the medicine which has on an intestinal motility obstacle and sharp pain
Document Type and Number:
Japanese Patent JP6259458
Kind Code:
B2
Abstract:
A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises:
a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and
b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.
Inventors:
Connolly, Emon
Kunze, Wolfgang
Beanenstock, John
Kunze, Wolfgang
Beanenstock, John
Application Number:
JP2015529067A
Publication Date:
January 10, 2018
Filing Date:
September 03, 2013
Export Citation:
Assignee:
Biogaia AB
International Classes:
G01N33/50; A61K35/74; A61P1/04; A61P1/06; A61P1/10; A61P1/14; C12N1/20; G01N33/15
Domestic Patent References:
| JP2002523351A | ||||
| JP2003507472A | ||||
| JP2004255180A |
Foreign References:
| WO2011148219A1 |
Other References:
R Wu et al.,Spatiotemporal maps of ex vivo peristalsis reveal details of probiotic effects on mouse jejunum motility,canadian journal of gastroenterology,2012年,Vol.26 Suppl A,Page.170A
Bingxian Wang et al.,Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility wthin minutes,FASEB J.,2010年,vol. 24, no. 10,4078-88
Bingxian Wang et al.,Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility wthin minutes,FASEB J.,2010年,vol. 24, no. 10,4078-88
Attorney, Agent or Firm:
Asamura patent office