【発明の名称】ジフルオロヌクレオシド類の選択的単離法

Japanese Patent JP2777359

B2

The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 α/β anomeric ratio, and processes for selectively isolating β-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 α/β mixture.

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TAASEN CHO
PERII KURAAKU HIISU
ROORENSU EDOWAADO PATAASON

JP22794697A

July 16, 1998

August 25, 1997

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IIRAI RIRII ANDO CO

A61K31/365; A61K31/70; A61K31/7024; A61K31/7042; C07H1/06; A61K31/7052; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P35/00; C07D307/32; C07D307/33; C07H7/02; C07H13/08; C07H19/056; C07H19/06; C07H19/067; C07H19/12; C07H19/16; C07H19/167; (IPC1-7): C07D307/33

Aoyama Ryo (1 person outside)

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