Title:
アミノ酸誘導体の光学異性体の分離方法
Document Type and Number:
Japanese Patent JP4783496
Kind Code:
B2
Abstract:
Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture with a hydrophilic compound such as beta -cyclodextrin having a different affinity to two kinds of the optical isomers described above and then bringing the resulting aqueous solution or aqueous suspension into contact with a hydrophobic substance such as a solid matter subjected on a surface thereof to hydrophobic treatment on the condition that the pH is 3.5 or lower or under the coexistence of ions including an atomic group having hydrophobicity which can be a counter ion for the amino acid derivative described above such as a triethylammonium ion to thereby separate the D type amino acid derivative from the L type amino acid derivative present in the above aqueous solution or aqueous suspension.
Inventors:
Shin Watanabe
Mizuhara Kawahara
Mizuhara Kawahara
Application Number:
JP2000335352A
Publication Date:
September 28, 2011
Filing Date:
November 02, 2000
Export Citation:
Assignee:
Tokuyama Corporation
International Classes:
C07C231/20; C07D207/16; C07B57/00; C07C233/83; C07C269/08; C07C271/22; C07C319/28; C07C323/52; C07D209/20; C07C323/58; C07C323/59
Other References:
JOURNAL OF LIQUID CHROMATOGRAPHY,(1992), Vol.15, No.9,p.1411-1429