ADJUSTMENT OF SIDE CHAIN VARIANT AND ENERGY BIOMARKER OF REDOX-ACTIVE THERAPY FOR TREATMENT OF MITOCHONDRIAL DISEASE AND OTHER SYMPTOMS

Japanese Patent JP2016047854

A

PROBLEM TO BE SOLVED: To provide a method for treating a mitochondrial disorder, adjusting one or more energy biomarkers, normalizing one or more energy biomarkers, or strengthening one or more energy biomarkers.SOLUTION: Disclosed are not only the treatment method or inhibiting method for mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactic acidosis, strokelike symptoms (MELAS), or Kearns-Sayre syndrome (KSS), but also a useful compound in the method. A useful method and compound for treatment of other diseases are disclosed. An energy biomarker useful for evaluation of a subject's metabolic state and the effect of the treatment is also disclosed. In addition to the method for adjusting, normalizing, or strengthening the energy biomarker, a compound useful in such a method is also disclosed.SELECTED DRAWING: None

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MILLER GUY M
HECHT SIDNEY M
JANKOWSKI ORION D
WESSON KIERON E
PAUL MOLLARD

JP2016000208A

April 07, 2016

January 04, 2016

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EDISON PHARMACEUTICALS INC

A61K31/05; A61K31/122; A61P3/10; A61P9/00; A61P9/10; A61P21/00; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00; A61P43/00; C07C50/04; C07C50/06

Hidesaku Yamamoto
Natsuki Morishita

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