Title:
絹糸生体材料およびその使用方法
Document Type and Number:
Japanese Patent JP5855151
Kind Code:
B2
Abstract:
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
Inventors:
Kaplan David L.
Jin Hyung-Joan
Rutridge Gregory
Friedrich Sergey
Jin Hyung-Joan
Rutridge Gregory
Friedrich Sergey
Application Number:
JP2014043805A
Publication Date:
February 09, 2016
Filing Date:
March 06, 2014
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
A61L27/00; A61K45/00; A61L27/22; A61L27/36; A61L27/44; A61L27/48; B32B27/06; C07K14/435; C08H1/00; C08L89/00; C12N5/07; C12N5/071; D01D5/00; D01F4/02; D01F6/88; D02G3/04; D04H1/728; D06M13/17; D06M15/00; D06M15/03; D06M15/11; C08J
Foreign References:
| US6110590 |
Other References:
J. Biomater. Sci. Polymer Edn,2001年,Vol.12, No.9,p.979-993
大郷耕輔 他,エレクトロスピニング法による家蚕絹及び野蚕絹フィブロインのナノ繊維の作成及びキャラクタリゼーション,高分子学会予稿集,2002年 5月,51巻,p.1109
大郷耕輔 他,エレクトロスピニング法による家蚕絹及び野蚕絹フィブロインのナノ繊維の作成及びキャラクタリゼーション,高分子学会予稿集,2002年 5月,51巻,p.1109
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
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