Title:
A single singularity and double singularity anti-IGF-1R antibody and anti-ERBB3 antibody
Document Type and Number:
Japanese Patent JP6214453
Kind Code:
B2
Abstract:
Provided herein are novel antiErbB3 and anti-IGF-IR antibodies (e.g., monoclonal antibodies). Also provided herein are novel monospecific and bispecific antibodies that are useful as anti neoplastic agents and that bind specifically to human IGF-IR and/or human ErbB3. Exemplary antibodies inhibit signal transduction through both or either of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-IR binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region.
Inventors:
Jason Baum
Brian johnson
Alexei Alexandrovich Lugovskoy
Li Hoi Shui
Nyrai Kori
Jonathan Basil Fitzgerald
Charlene Adams
Brian johnson
Alexei Alexandrovich Lugovskoy
Li Hoi Shui
Nyrai Kori
Jonathan Basil Fitzgerald
Charlene Adams
Application Number:
JP2014080445A
Publication Date:
October 18, 2017
Filing Date:
April 09, 2014
Export Citation:
Assignee:
Merrimack Pharmaceuticals Inc.
International Classes:
C07K16/46; A61K39/395; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| JP5588086B2 |
Foreign References:
| US20110044980 | ||||
| WO2008108986A1 | ||||
| WO2008140493A1 | ||||
| WO2011028811A1 | ||||
| WO2010019952A1 | ||||
| WO2011022727A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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