Title:
The spiro condensation piperidine derivative used as a prevention medicine of a kidney medullary substance outer layer potassium channel
Document Type and Number:
Japanese Patent JP6166783
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Inventors:
Dean, Huar-Shearn
Dawn
Free, Jessica
Gu, Shin
Jean, Jin Loan
Alexander Pasternak
Turn, hyphen
Woo, Jetseye
Yui, Yarn
Takao Suzuki
Dawn
Free, Jessica
Gu, Shin
Jean, Jin Loan
Alexander Pasternak
Turn, hyphen
Woo, Jetseye
Yui, Yarn
Takao Suzuki
Application Number:
JP2015524451A
Publication Date:
July 19, 2017
Filing Date:
July 25, 2013
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D471/10; A61K31/438; A61K31/439; A61K31/46; A61K31/4995; A61K31/5386; A61K45/00; A61P1/16; A61P3/10; A61P7/00; A61P7/02; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P13/12; A61P15/08; A61P25/00; A61P43/00; C07D471/20; C07D498/20; C07D519/00
Foreign References:
| WO2010129379A1 | ||||
| WO2012058134A1 | ||||
| WO2012058116A1 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
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