Title:
STABILIZED PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JP2016145258
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition in which the increase in impurities accompanying the preparation of benzimidazole-7-carboxylic acid represented by candesartan or candesartan cilexetil or its derivative is suppressed, and reduction with time in the contents is prevented, and a method for preparing the composition.SOLUTION: A stable pharmaceutical composition can be obtained when benzimidazole-7-carboxylic acid or its derivative is blended with polyhydric alcohol. Namely, a technical ethic is established that the addition of polyhydric alcohol remarkably suppresses the decomposition of effective components, suppresses the increase in impurities accompanying the preparation, and prevents the reduction with time in the contents of the effective components.SELECTED DRAWING: None
Inventors:
IWANE HIDENORI
MOCHIZUKI RYOSUKE
YASUI MASAMI
MOCHIZUKI RYOSUKE
YASUI MASAMI
Application Number:
JP2016098329A
Publication Date:
August 12, 2016
Filing Date:
May 16, 2016
Export Citation:
Assignee:
TEVA PHARMA JAPAN INC
International Classes:
A61K31/4184; A61K47/34; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12
Domestic Patent References:
| JP2005330277A | 2005-12-02 |
Foreign References:
| WO2009135646A2 | 2009-11-12 |
Attorney, Agent or Firm:
Ryu Iwatani
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