Title:
【発明の名称】食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び/又は代謝症候群の治療のための薬剤の調製に使用する物質
Document Type and Number:
Japanese Patent JP2003521528
Kind Code:
A
Abstract:
A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.
Inventors:
Hermansen, Kelda
Gregersen, Selenium
Jeppesen, Par, Bendix
Gregersen, Selenium
Jeppesen, Par, Bendix
Application Number:
JP2001556812A
Publication Date:
July 15, 2003
Filing Date:
February 01, 2001
Export Citation:
Assignee:
Stevia, Apes
International Classes:
A61K31/015; A61K31/045; A61K31/19; A61K31/352; A61K31/7034; A61K31/704; A61K36/00; A61K36/28; A61K36/48; A61K45/06; A61P3/00; A61P3/04; A61K38/00; A61P3/06; A61P3/10; A61P9/12; C07C13/64; C07C13/68; C07C61/35; C07H15/24; C07H15/256; (IPC1-7): A61K31/19; A61K31/352; A61K31/7034; A61K31/704; A61K35/78; A61K38/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/12
Domestic Patent References:
| JPH06157302A | 1994-06-03 | |||
| JP2002500677A | 2002-01-08 |
Other References:
DIABETOLOGIA, vol. 39, no. 1, JPN6011021571, 1996, pages 125, ISSN: 0001905961
CELL SIGNALLING, vol. 10,10, JPN6011021572, 1998, pages 727 - 733, ISSN: 0001905962
CRAIG JOHN C, PHYTOCHEMISTRY, vol. V15, JPN5002021594, 1976, pages 1178, ISSN: 0001905963
CELL SIGNALLING, vol. 10,10, JPN6011021572, 1998, pages 727 - 733, ISSN: 0001905962
CRAIG JOHN C, PHYTOCHEMISTRY, vol. V15, JPN5002021594, 1976, pages 1178, ISSN: 0001905963
Attorney, Agent or Firm:
Yoshitaka Sonoda (1 outside)