Title:
細胞接着インヒビターとしての置換ラクトース誘導体
Document Type and Number:
Japanese Patent JPH09511233
Kind Code:
A
Abstract:
Compounds and methods of making them having the following formula are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events: wherein each R1 is independently H or lower alkyl (1-4C); R2 is H, OH or lower alkyl (1-4C), or a lipophilic group such as a higher alkyl group (5-15C), alkylaryl or one or more additional saccharide residues; R3 is a negatively charged moiety including SO42-, PO42-, or related group; Y is H or lower alkyl (1-4C); and X is H or -CHR4(CHOR1)2CHR5OR1 wherein R4 and R5 are each independently H, lower alkyl (1-4C), or taken together result in a five- or six-membered ring optionally containing a heteroatom selected from the group consisting of O, S, and NR1; the five- or six-membered ring optionally substituted with one substituent selected from the group consisting of R1, CH2OR1, OR1, OOCR1, NR12, NHCOR1, and SR1 with the proviso that if X represents a hexose substituent R3 and R4, taken together, cannot provide a hexose substituent.
Inventors:
アサ，ダーウィン
アブバス， サイード エイ．
ダスガプタ， ファルグニ
ナッシュド， ミナ エイ．
ムッサー， ジョン エイチ．
アブバス， サイード エイ．
ダスガプタ， ファルグニ
ナッシュド， ミナ エイ．
ムッサー， ジョン エイチ．
Application Number:
JP52070695A
Publication Date:
November 11, 1997
Filing Date:
February 01, 1995
Export Citation:
Assignee:
グライコメッド インコーポレイテッド
International Classes:
C07H15/04; A61K31/70; A61K31/7028; A61K31/7042; A61K31/7048; A61P9/08; A61P9/10; A61P29/00; A61P35/00; A61P37/06; C07H3/04; C07H3/06; C07H11/00; C07H15/18; C07H17/04; C07H23/00; (IPC1-7): C07H15/04; A61K31/70; C07H17/04
Attorney, Agent or Firm:
山本 秀策