Title:
5-HT6アンタゴニストとしてのスルホニルピラゾリンカルボキサミジン誘導体
Document Type and Number:
Japanese Patent JP2010504302
Kind Code:
A
Abstract:
This invention concerns compounds of the general formula (1): and derivatives thereof, which are antagonists of 5-HT6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.
Inventors:
Ivema Butzkar, Wooter Eye
Kaiser, Hischias G
Neut, Van der, Martina A. Davryu
Kruze, Cornelis G
Loben Jean, Van, Arnold
Zorg Drager, Yang
Kaiser, Hischias G
Neut, Van der, Martina A. Davryu
Kruze, Cornelis G
Loben Jean, Van, Arnold
Zorg Drager, Yang
Application Number:
JP2009528720A
Publication Date:
February 12, 2010
Filing Date:
September 20, 2007
Export Citation:
Assignee:
Solvay Pharmaceuticals B.V.
International Classes:
C07D231/06; A61K31/415; A61K31/4155; A61K31/416; A61K31/4162; A61K31/428; A61K31/429; A61K31/4355; A61K31/437; A61K31/438; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/538; A61P1/00; A61P1/06; A61P1/12; A61P3/04; A61P3/10; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D231/18; C07D231/54; C07D231/56; C07D401/04; C07D401/12; C07D403/12; C07D405/04; C07D405/12; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D471/04; C07D471/10; C07D491/107; C07D513/04; C07D519/00
Foreign References:
| WO2001070700A1 | 2001-09-27 | |||
| WO2003026647A1 | 2003-04-03 | |||
| WO2003026648A1 | 2003-04-03 |
Other References:
J.HETEROCYCLIC.CHEM., vol. 39(2), JPN6012054875, 2002, pages 363 - 366, ISSN: 0002360909
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
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