Title:
A synthesizing method of 18F sign biomolecule
Document Type and Number:
Japanese Patent JP6244303
Kind Code:
B2
Abstract:
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.
Inventors:
Robert Anne Dommet, Neane
Burra, rajiv
Khan, The Imitations
Brown, jane
Wilson, Anthony
Black, Andrew
Burra, rajiv
Khan, The Imitations
Brown, jane
Wilson, Anthony
Black, Andrew
Application Number:
JP2014535116A
Publication Date:
December 06, 2017
Filing Date:
October 15, 2012
Export Citation:
Assignee:
GE HEALTHCARE LIMITED
International Classes:
C07B59/00; C07C319/14; C07C323/44
Domestic Patent References:
| JP2008546755A | ||||
| JP2008524205A | ||||
| JP2006528648A |
Foreign References:
| WO2011042550A1 |
Other References:
ZUHAYRA, M et al.,New approach for the synthesis of [18F]fluoroethyltyrosine for cancer imaging: Simple, fast, and high yielding automated synthesis,Bioorganic & Medicinal Chemistry,2009年,17(21),7441-7448
PRANTE, OLAF et al.,Synthesis, Radiofluorination, and In Vitro Evaluation of Pyrazolo[1,5-a]pyridine-Based Dopamine D4 Receptor Ligands: Discovery of an Inverse Agonist Radioligand for PET,Journal of Medicinal Chemistry,2008年,51(6),1800-1810
WILSON ALAN A,SYNTHESIS OF TWO RADIOFLUORINATED COCAINE ANALOGUES 以下省略,APPLIED RADIATION AND ISOTOPES,英国,ELSEVIER,1995年 8月 1日,V46 N8,P765-770
MINGWEI WANG,JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,KLUWER ACADEMIC PUBLISHERS,2006年11月 1日,V270 N2,P439-443
LUNDKVIST CAMILLA,NUCLEAR MEDICINE AND BIOLOGY,米国,ELSEVIER,1997年10月 1日,V24 N7,P621-627
ZHANG MING-RONG,APPLIED RADIATION AND ISOTOPES,英国,ELSEVIER,2002年 9月 1日,V57 N3,P335-342
Journal of the American Chemical Society,2006年,128(50),16394-16397
PRANTE, OLAF et al.,Synthesis, Radiofluorination, and In Vitro Evaluation of Pyrazolo[1,5-a]pyridine-Based Dopamine D4 Receptor Ligands: Discovery of an Inverse Agonist Radioligand for PET,Journal of Medicinal Chemistry,2008年,51(6),1800-1810
WILSON ALAN A,SYNTHESIS OF TWO RADIOFLUORINATED COCAINE ANALOGUES 以下省略,APPLIED RADIATION AND ISOTOPES,英国,ELSEVIER,1995年 8月 1日,V46 N8,P765-770
MINGWEI WANG,JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,KLUWER ACADEMIC PUBLISHERS,2006年11月 1日,V270 N2,P439-443
LUNDKVIST CAMILLA,NUCLEAR MEDICINE AND BIOLOGY,米国,ELSEVIER,1997年10月 1日,V24 N7,P621-627
ZHANG MING-RONG,APPLIED RADIATION AND ISOTOPES,英国,ELSEVIER,2002年 9月 1日,V57 N3,P335-342
Journal of the American Chemical Society,2006年,128(50),16394-16397
Attorney, Agent or Firm:
Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa
Takuto Tanaka
Hirokazu Ogura
Toshihisa Kurokawa
Takuto Tanaka
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