Title:
カンプトテシン関連化合物の合成方法
Document Type and Number:
Japanese Patent JP4805967
Kind Code:
B2
Abstract:
The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
Inventors:
Takanori Ogawa
Hiroyuki Nishiyama
Uchida Miyuki
Seigo Sawada
Hiroyuki Nishiyama
Uchida Miyuki
Seigo Sawada
Application Number:
JP2008085358A
Publication Date:
November 02, 2011
Filing Date:
March 28, 2008
Export Citation:
Assignee:
Yakult Honsha Co., Ltd.
International Classes:
C07C221/00; C07C205/19; C07C205/22; C07C205/37; C07C205/44; C07C205/45; C07C225/22; C07D213/64; C07D491/04; C07D491/052; C07D491/14; C07D491/147; C07D491/22
Domestic Patent References:
| JP10503525A | ||||
| JP8225482A | ||||
| JP7101956A |
Foreign References:
| US5391745 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa