Title:
キナーゼ阻害剤としてのテトラヒドロシクロペンタ［ｃ］アクリジン誘導体およびその生物学的適用
Document Type and Number:
Japanese Patent JP5879036
Kind Code:
B2
Abstract:
The invention relates to kinase inhibitors of the formula (I) in which —R1 to R4═H; ether or polyether, amino; NO2; NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; —R5=—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; N(R9,R10); —R5′═H or a C1-C12 alkyl, —R6═H; R; (R or R′)3—Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R7 and R8═H, C1-C12 alkyl; —R9 and R10═H, R (or R′) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.
Inventors:
Belmont Philip Olivier
Meyer Laurent
Cohen philippe
Pattern Amori
Bosson Johann
Gauge Ann Peter Gregory
Meyer Laurent
Cohen philippe
Pattern Amori
Bosson Johann
Gauge Ann Peter Gregory
Application Number:
JP2010542727A
Publication Date:
March 08, 2016
Filing Date:
January 19, 2009
Export Citation:
Assignee:
Saintur Nacional de la Rushche Shandifique
International Classes:
A61K31/695; A61K31/475; A61P3/10; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D219/06; C07F7/10
Foreign References:
| EP0268871A1 |
Other References:
PATIN AMAURY,A NEW ROUTE TO ACRIDINES: PAUSON-KHAND REACTION ON QUINOLINE-BEARING 1-EN-7-YNESLEADING TO NOVEL TETRAHYDROCYCLOPENTA[C]ACRIDINE-2,5-DIONES,SYNTHESIS,2005年,N14,P2400-2406
Otto Meth-Cohnほか,A VERSATILE NEW SYNTHESIS OF QUINOLINES AND BELATED FUSED PYEIDINES. PART II.,TETRAHEDRON LETTERS,1979年,Vol. 20, No. 33,pp. 3111-3114
Otto Meth-Cohnほか,A VERSATILE NEW SYNTHESIS OF QUINOLINES AND BELATED FUSED PYEIDINES. PART II.,TETRAHEDRON LETTERS,1979年,Vol. 20, No. 33,pp. 3111-3114
Attorney, Agent or Firm:
Norihiko Hibi
Einosuke Kishimoto
Akira Watanabe
Matsumura Naoto
Einosuke Kishimoto
Akira Watanabe
Matsumura Naoto
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