Title:
ヒアルロン酸生成促進剤を含有する退行性関節炎治療剤
Document Type and Number:
Japanese Patent JP4580242
Kind Code:
B2
Abstract:
There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (compound K), a chief metabolite of ginseng saponin, to increase the expression of hyaluronic acid synthase gene in human cell and thereby to promote the production of hyaluronic acid, and an anti-aging agent containing the promoter for the production of hyaluronic acid as an effective ingredient.
Inventors:
Kim Soo Young
Kim Byung Young
Choice
Chang Uikyeong
Sand Eso
Yong Myung Ho
Ok
Kim Dak Hee
Kim han kong
Sim Young Chul
Kanhakuhi
Lyon Sun
Kim Byung Young
Choice
Chang Uikyeong
Sand Eso
Yong Myung Ho
Ok
Kim Dak Hee
Kim han kong
Sim Young Chul
Kanhakuhi
Lyon Sun
Application Number:
JP2004562980A
Publication Date:
November 10, 2010
Filing Date:
September 16, 2003
Export Citation:
Assignee:
AMOREPACIFIC CORPORATION
International Classes:
A61K31/7028; C07J17/00; A61K31/704; A61P19/02; A61P43/00; A61K8/63; A61P17/00; A61Q19/08
Domestic Patent References:
| JP2003212776A | ||||
| JP2003238424A |
Foreign References:
| WO1997031013A1 |
Other References:
LEE, S.,Induction of Apoptosis by a Novel Intestinal Metabolite of Ginseng Saponin via Cytochrome c-Mediated Activation of Caspase-3 Protease,Biochemical Pharmacology ,2000年,60(5),p. 677-685
HASEGAWA, H.,Metabolic activation of ginsenoside against cancer: Intestinal bacterial deglycosylation and hepatic fatty-acid esterification,和漢医薬学雑誌,2001年,18(6),p. 217-228
MATSUDA, H.,Anti-inflammatory activity of ginsenoside Ro,Planta Med,1990年,56(1),p. 19-23
HASEGAWA, H.,Metabolic activation of ginsenoside against cancer: Intestinal bacterial deglycosylation and hepatic fatty-acid esterification,和漢医薬学雑誌,2001年,18(6),p. 217-228
MATSUDA, H.,Anti-inflammatory activity of ginsenoside Ro,Planta Med,1990年,56(1),p. 19-23
Attorney, Agent or Firm:
Katsuo Naruse
Tomohiro Nakamura
Tomohiro Nakamura