Title:
１７β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての治療的に活性な１７−窒素置換エストラトリエンチアゾール誘導体
Document Type and Number:
Japanese Patent JP6556125
Kind Code:
B2
Abstract:
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2 to R7 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD and in treatment or prevention of steroid hormone de-pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17β-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the afore-mentioned compounds or pharmaceutically acceptable salts thereof.
Inventors:
Ero lanta, email
Hilbera, Lina
Cangas, Lauri
Koskimies, Pasi
La mintausta, list
Unkira, Mikko
Hilbera, Lina
Cangas, Lauri
Koskimies, Pasi
La mintausta, list
Unkira, Mikko
Application Number:
JP2016522679A
Publication Date:
August 07, 2019
Filing Date:
June 25, 2014
Export Citation:
Assignee:
Forend Pharma Limited
International Classes:
A61K31/58; C07J43/00; A61K45/00; A61P3/04; A61P5/24; A61P13/00; A61P13/08; A61P15/00; A61P17/00; A61P19/02; A61P27/12; A61P29/00; A61P35/00; A61P43/00; C07J71/00
Domestic Patent References:
| JP2008545678A | ||||
| JP2004537499A | ||||
| JP2010511010A |
Foreign References:
| WO2004085457A1 | ||||
| US20060281710 | ||||
| US20080255075 |
Other References:
J. Med. Chem.,2006年,49,1325-1345
J. Med. Chem.,2005年,48,5749-5770
Bioorg. Med. Chem. Lett.,2009年,19,6740-6744
Bioorg. Med. Chem.,2008年,16,1849-1860
BROI P; LANINIK RINER T; GOBEC S,INHIBITORS OF 17-HYDROXYSTEROID DEHYDROGENASE TYPE 1,CURRENT MEDICINAL CHEMISTRY,NL,BENTHAM SCIENCE PUBLISHERS,2008年 1月 1日,VOL:15 NR:2,PAGE(S):137 - 150
J. Med. Chem.,2005年,48,5749-5770
Bioorg. Med. Chem. Lett.,2009年,19,6740-6744
Bioorg. Med. Chem.,2008年,16,1849-1860
BROI P; LANINIK RINER T; GOBEC S,INHIBITORS OF 17-HYDROXYSTEROID DEHYDROGENASE TYPE 1,CURRENT MEDICINAL CHEMISTRY,NL,BENTHAM SCIENCE PUBLISHERS,2008年 1月 1日,VOL:15 NR:2,PAGE(S):137 - 150
Attorney, Agent or Firm:
Hanabusa Patent and Trademark Office