Title:
多発性硬化症の治療のための、フマル酸モノメチルエステルとピペラジン又はエチレンジアミンとの３つの成分の塩
Document Type and Number:
Japanese Patent JP6564868
Kind Code:
B2
Abstract:
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of salts of formula I or formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurodegenerative diseases and psoriasis.
Inventors:
Mahesh Kandura
Application Number:
JP2017541179A
Publication Date:
August 21, 2019
Filing Date:
December 29, 2014
Export Citation:
Assignee:
CELLIX BIO PRIVATE LIMITED
International Classes:
C07D295/027; A61K31/225; A61K31/495; A61P17/06; A61P25/00; A61P29/00; A61P37/02; C07C57/03; C07C69/60; C07C211/10
Domestic Patent References:
| JP2014515373A | ||||
| JP2013521301A |
Foreign References:
| WO2013119677A1 | ||||
| WO2013175359A1 | ||||
| WO2007006307A1 |
Other References:
CHEN. Songela, et al.,n-3 PUFA supplementation benefits microglial responses to myelin pathology,Scientific Reports,2014年,4,1-8,DOI:10.1038/srep07458
UNODA. Kiichi, et al.,Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis,Journal of Neuroimmunology,2013年,256,7-12
UNODA. Kiichi, et al.,Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis,Journal of Neuroimmunology,2013年,256,7-12
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office