PURPOSE: To obtain a compound by using optically active mandelic acid as a resolving agent and adding bis(α-methylbenzyl)amine and salts to a reactional system and resolving (RS)-α-methylbenzylamine.
CONSTITUTION: (RS)-α-Methylbenzylamine is made to react with optically active mandelic acid in the presence of a bis(α-methylbenzyl)amine of formula I (* indicates asymmetric carbon) and a salt of ammonia or a primary amine with an inorganic acid or an organic acid (e.g. ammonium chloride) and/or water-soluble inorganic salts (e.g. potassium nitrate) in an aqueous medium to afford the objective sparingly soluble optically active diastereomer salt of formula II. Since a crystal of the deposited sparingly soluble diastereomer salt is obtained as a thick hexagonal platy crystal or a rhombic crystal good in filtrability, the product of high optical purity can readily be produced.
MURAKAMI NAOMICHI
SAIGO KAZUHIKO
NOHIRA HIROYUKI
