Title:
A treating method of protei Notchy
Document Type and Number:
Japanese Patent JP6061922
Kind Code:
B2
Abstract:
The present disclosure provides technologies relating to lysosomal activation. The disclosure provides several strategies for increasing level and/or activity of lysosomal enzyme, and furthermore demonstrates the surprising applicability of such strategies in the treatment and/or prophylaxis of certain proteinopathies. Among other things, the present invention provides methods and compositions for the treatment and/or prophylaxis of proteinopathies other than lysosomal storage diseases through lysosomal activation. In particular, the present disclosure provides methods and compositions for the treatment and/or prophylaxis of neurodegenerative proteinopathies, and in particular those associated with accumulation of α-synuclein. The present disclosure specifically provides methods and compositions for the treatment and/or prophylaxis of Parkinson's disease.
Inventors:
Clark Dmitri
Matturi Joseph Earl.
Matturi Joseph Earl.
Application Number:
JP2014517206A
Publication Date:
January 18, 2017
Filing Date:
June 22, 2012
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
A61K31/519; A61P21/02; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P43/00
Domestic Patent References:
| JP2009541489A | ||||
| JP2008509223A | ||||
| JP2013544893A |
Other References:
Molecular Genetics and Metabolism,2011年 2月,Vol.102, Issue 2,S12の左上記事
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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