Title:
向神経活性１９−アルコキシ−１７−置換ステロイド、そのプロドラッグおよびそれを使用する処置方法
Document Type and Number:
Japanese Patent JP2016503793
Kind Code:
A
Abstract:
本発明は、一般に、例えば、麻酔剤としておよび／またはＧＡＢＡ機能および活性と関係する障害の処置に使用するための、ここに記載する向神経活性１９−アルコキシ−１７−置換ステロイドおよび薬学的に許容されるその塩に関する。本発明は、さらにこのような化合物を含む医薬組成物に関する。
Inventors:
Douglas Coby
Albert Jean Rovishaw
Albert Jean Rovishaw
Application Number:
JP2015549643A
Publication Date:
February 08, 2016
Filing Date:
December 18, 2013
Export Citation:
Assignee:
Washington University
SAGE THERAPEUTICS,INC.
SAGE THERAPEUTICS,INC.
International Classes:
C07J1/00; A61K31/568; A61K31/5685; A61K31/57; A61K31/573; A61P9/10; A61P11/06; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P43/00; C07J3/00; C07J5/00; C07J7/00; C07J41/00
Domestic Patent References:
| JP2007512344A | 2007-05-17 | |||
| JPH11507643A | 1999-07-06 | |||
| JP2010530004A | 2010-09-02 |
Foreign References:
| WO2012013816A1 | 2012-02-02 |
Other References:
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PECHET,M.M. ET AL: "Metabolism of 19-hydroxycorticosterone. Isolation and characterization of three metabolites", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 236, JPN6017031389, 1961, pages 68 - 9, ISSN: 0003956395
GUSTAFSSON,J.A.: "Steroids in germ-free and conventional rats. VII. Identification of C19 and C21 steroids in feces", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 6, no. 2, JPN6017031390, 1968, pages 248 - 55, ISSN: 0003956396
GUSTAFSSON,J.A. ET AL: "Steroid excretion patterns in urine from ovariectomized and adrenalectomized rats", BIOCHIMICA ET BIOPHYSICA ACTA, LIPIDS AND LIPID METABOLISM, vol. 280, no. 1, JPN6017031391, 1972, pages 182 - 6, XP025901688, ISSN: 0003956397, DOI: 10.1016/0005-2760(72)90223-8
SHEN,J. ET AL: "Microbial aromatization of 19-hydroxymethylepidehydroandrosterone acetate by Corynebacterium simplex", HUAXUE XUEBAO, vol. 41, no. 5, JPN6017031392, 1983, pages 473 - 4, ISSN: 0003956398
WICHA,J. ET AL, TETRAHEDRON, JPN6017031393, 1969, pages 3961 - 3968, ISSN: 0003956399
HAN,M. ET AL, J.MED.CHEM, vol. 38, JPN6017031395, 1995, pages 4548 - 4556, ISSN: 0003956392
CERNY,I. ET AL, STEROIDS, vol. 71, JPN6017031387, 2006, pages 120 - 128, ISSN: 0003956393
WICHA,J. ET AL, J.ORG.CHEM., vol. 38, no. 7, JPN6017031388, 1973, pages 1280 - 1283, ISSN: 0003956394
PECHET,M.M. ET AL: "Metabolism of 19-hydroxycorticosterone. Isolation and characterization of three metabolites", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 236, JPN6017031389, 1961, pages 68 - 9, ISSN: 0003956395
GUSTAFSSON,J.A.: "Steroids in germ-free and conventional rats. VII. Identification of C19 and C21 steroids in feces", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 6, no. 2, JPN6017031390, 1968, pages 248 - 55, ISSN: 0003956396
GUSTAFSSON,J.A. ET AL: "Steroid excretion patterns in urine from ovariectomized and adrenalectomized rats", BIOCHIMICA ET BIOPHYSICA ACTA, LIPIDS AND LIPID METABOLISM, vol. 280, no. 1, JPN6017031391, 1972, pages 182 - 6, XP025901688, ISSN: 0003956397, DOI: 10.1016/0005-2760(72)90223-8
SHEN,J. ET AL: "Microbial aromatization of 19-hydroxymethylepidehydroandrosterone acetate by Corynebacterium simplex", HUAXUE XUEBAO, vol. 41, no. 5, JPN6017031392, 1983, pages 473 - 4, ISSN: 0003956398
WICHA,J. ET AL, TETRAHEDRON, JPN6017031393, 1969, pages 3961 - 3968, ISSN: 0003956399
Attorney, Agent or Firm:
Samejima Mutsumi
Kyousei Tamura
Yasushi Morimoto
Kyousei Tamura
Yasushi Morimoto