トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物

Japanese Patent JP5765753

B2

The present invention provides novel compounds having a P2X 3 and/or P2X 2 / 3 receptor antagonistic effect. A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein R h and R j are taken together to form a bond; R a and R b and/or R d and R e are taken together to form oxo or the like; R c is hydrogen, substituted or unsubstituted alkyl or the like; R f is -(CR 4a R 4b )n-R 2 ; R 4a and R 4b are hydrogen, substituted or unsubstituted alkyl or the like; R 2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; -R g is -X-R 3 ; -X- is -O-, -S- or the like; R 3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.

Hiroyuki Kai
Takayuki Kameyama
Toru Horiguchi
Kentaro Asahi
Takeshi Endo
Yasuhiko Fujii
Takuya Shintani
Kenichiro Nakamura
Ayae Naohara
Go Hasegawa
Miho Ohara
Yukio Tada
Toshikatsu Maki
Sei Iida

JP2014153414A

August 19, 2015

July 29, 2014

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Shionogi Pharmaceutical Co., Ltd.

C07D251/46; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D405/04; C07D405/06; C07D405/12; C07D405/14; C07D409/12; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D417/14

JP5310715A
JP2004501120A
JP54154779A

Hiromitsu Takayama
Kenichi Sugita

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