The use as 2 substitution benzothienyl pyrrolo triazine and FGFR inhibitor

Japanese Patent JP6050829

B2

This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.

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Dirk Broome
Melanie Eleu
Marie-Piere Colin
Walter Hupsch
Mario Robert
Clemens Rustig
Sirvia Grunewald
Wolf Boehmer
Ferrena Fehringer

JP2014546445A

December 21, 2016

December 10, 2012

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Bayer Intellectual Property GmbH

A61K31/53; C07D487/04; A61K31/5355; A61K31/5377; A61K31/541; A61P35/00; A61P43/00

JP2009519222A
JP2009522284A
JP2009519905A
JP2003500359A

Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Takuya Gomibuchi
Yoshikazu Iwase
Yasufumi Shiroyama

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