The use as the new Thio derivative which has the lactam as powerful HDAC inhibitor, and a medical treatment agent - SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI

Title:

The use as the new Thio derivative which has the lactam as powerful HDAC inhibitor, and a medical treatment agent

Document Type and Number:

Japanese Patent JP6053795

Kind Code:

B2

Abstract:

The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of HDAC is responsive, and the pharmaceutical composition containing such compounds.

Inventors:

Giuseppe Giannini
Walter Cabris
Gianfranco Battistuzzi
David Vignola
Nicola Phanto
Claudio Pisano
Loredana Wessi

Application Number:

JP2014530260A

Publication Date:

December 27, 2016

Filing Date:

September 17, 2012

Export Citation:

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Assignee:

SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI

International Classes:

C07D205/08; A61K31/397; A61K31/4015; A61K31/4412; A61K31/45; A61K31/4545; A61P9/10; A61P19/02; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P29/00; A61P33/06; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07D207/277; C07D207/28; C07D211/78; C07D211/90; C07D401/12

Domestic Patent References:

JP5117232A
JP2007514700A

Foreign References:

WO2005051901A1
US6511990

Other References:

Itoh, Y. et al,J. Med. Chem.,2007年,vol.50,p.5425-5438

Attorney, Agent or Firm:

Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro

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