Title:
新規大環状アミジノ尿素誘導体、その調製方法及びキチナーゼ阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP6586416
Kind Code:
B2
Abstract:
The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
Inventors:
Stefania Sanfilipo
Brunella Postello
Maurizio Sanguinetti
Maurizio Botta
Giorgio McCali
Philomena de Luca
Jean-Dennis Docquier
David Deodato
Brunella Postello
Maurizio Sanguinetti
Maurizio Botta
Giorgio McCali
Philomena de Luca
Jean-Dennis Docquier
David Deodato
Application Number:
JP2016520477A
Publication Date:
October 02, 2019
Filing Date:
June 18, 2014
Export Citation:
Assignee:
Signet Biosciences B.F.
International Classes:
C07D273/00; A61K31/5395; A61K45/00; A61P11/00; A61P11/06; A61P31/10; A61P37/08; A61P43/00; C07C279/24; C07D413/04
Domestic Patent References:
| JP2011513477A |
Other References:
Manetti, Fabrizio et al.,Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp.,J.Med. Chem,2009年,vol.52,pp.7376-7379
Sanguinetti, Maurizio et al.,Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species,Medicinal Chemistry Letters,2013年,vol.4 no.9,pp.852-857
Sanguinetti, Maurizio et al.,Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species,Medicinal Chemistry Letters,2013年,vol.4 no.9,pp.852-857
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe