Title:
fac型金属トリカルボニル化合物の調製方法および生物活性基質の標識化におけるその使用
Document Type and Number:
Japanese Patent JP4357597
Kind Code:
B2
Abstract:
The invention relates to a method of preparing a compound of the general formula fac-ÄM(CO)3(OH2)3Ü<+> wherein M is Mn, <99m>Tc, <186>Re or <188>Re, by reacting a metal in the permetallate form with carbon monoxide and a reducing agent, characterized in that a mixture of a base, a reducing agent soluble in water but not substantially decomposed by water, and optionally a stabilizing agent is solved in a water containing solvent system containing a solution of the metal in the permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide and optionally in the presence of a halide. The invention further relates to a method of preparing a labelled compound with the aid of the compound of general formula I, to a method of direct preparation of labeled compounds, to a method of labeling of substrates such as amino acids, peptides, proteins, sugars, small receptor binding molecules and body cells with the aid of compound of general formal I and to a kit for the preparation of a labelling composition and a kit for the preparation of a diagnostic of therapeutic pharmaceutical composition.
Inventors:
Roger Albert
Sibri, Roger
Egli, Andre
Sibri, Roger
Egli, Andre
Application Number:
JP54639198A
Publication Date:
November 04, 2009
Filing Date:
April 21, 1998
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
A61K51/00; A61K51/04; C07D233/26; C01G45/04; C01G47/00; C01G99/00; C07B59/00; C07D213/53; C07D213/72; C07D471/04; C07F13/00; C07J43/00; C07K1/13; C07K7/08; C07K16/00
Other References:
J. Chem. Soc. Dalton Trans, 1978年, 1巻, P.4-8
Journal of Organometallic Chemistry, 1995年, 493巻, P.119-127
Journal of Organometallic Chemistry, 1995年, 493巻, P.119-127
Attorney, Agent or Firm:
Takeshi Oshio