Title:
【発明の名称】サリチル単位から誘導された新規二芳香族化合物、その製法ならびにヒトおよび動物医薬ならびに化粧品におけるその使用
Document Type and Number:
Japanese Patent JP3244271
Kind Code:
B2
Abstract:
Diaromatic compounds, characterised in that they correspond to the following general formula: in which: R1 is -CH3, -CH2OH, -COR8 or -CH2OCOR9, R8 is H, OH, -OR10, -N(rr') or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl, aralkyl, and the like, r and r' together form a heterocycle, R9 is alkyl, alkenyl or a sugar residue, R2 and R3 are -OR11 or -OCOR11, R11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R3 additionally being H, R4 is H, OH, alkyl, alkoxy, F, Cl or -CF3, R5 and R7 are H, OH, alkoxy, substituted alkyl or alpha , alpha '-disubstituted alkyl, and the like, R6 is H, OH, alkyl, alkoxy, cycloalkyl, and the like, it not being possible for R5 and R7 to be simultaneously OH or alkoxy and it not being possible for R4, R5, R6 and R7 to be simultaneously H, R5 and R6 or R6 and R7 can form, with the aromatic ring, a 5- or 6-membered ring, X is chosen from: (i) -C(R13R14)-C(R16R18)-W-, (ii) -C(R14R16)-W-C(R18R19)-, (iii) -C(R13R14)-C(R15R16)-C(R18R20)-, (iv) -CR17=CR21-C(R13R14)- in which: W is O, -NR12 or S(O)n, n = 0, 1 or 2, R13, R15 and R20 are H, -OR11, -OCOR11, and the like, R14, R16, R18 and R19 are H, aralkyl, alkyl, and the like, when X is (i), R13 and R14 can form =N-OR11 or =N-OCOR11, when X is (iii) or (iv), R14, R16 and R18 are also -OR11 or -OCOR11, or R13, R14 or R15, R16 taken together can form =NOR11 or =N-OCOR11, R12 is H, alkyl, aralkyl, alkenyl, alkynyl or fluoroalkyl, R17 is H, hydroxyl, alkyl or alkoxy, R21 is H or alkyl, and the salts of the compounds of formula (I).
Inventors:
Bernardon, Jean-Michel
Application Number:
JP50984992A
Publication Date:
January 07, 2002
Filing Date:
May 13, 1992
Export Citation:
Assignee:
Centre Antel National de Ruchelche Dermatology Garderma
International Classes:
A61K31/047; A61K31/165; A61K31/19; A61K31/235; A61K31/445; A61K31/535; A61K31/5375; A61P17/00; A61P17/10; A61P17/14; A61P17/16; A61P27/02; A61P27/14; A61P29/00; A61P35/00; A61P37/08; C07C39/15; C07C39/21; C07C43/205; C07C43/23; C07C65/17; C07C65/19; C07C65/24; C07C65/26; C07C65/40; C07C69/017; A61K31/085; C07C69/63; C07C69/65; C07C69/86; C07C69/92; C07C217/48; C07C229/54; C07C229/64; C07C233/65; C07C235/46; C07C235/60; C07C237/30; C07C251/48; C07C317/00; C07C321/00; C07C323/00; C07D295/192; C07D295/22; (IPC1-7): C07C39/15; A61K31/085; A61K31/165; A61K31/19; A61K31/235; A61K31/445; A61K31/535; A61P17/10; A61P17/14; A61P17/16; C07C39/21; C07C43/205; C07C43/23; C07C65/24; C07C69/63; C07C69/65; C07C217/48; C07C229/54; C07C233/65; C07C235/46; C07C237/30; C07C251/48; C07C317/00; C07C321/00; C07C323/00; C07D295/22
Domestic Patent References:
| JP5395705A | ||||
| JP5239679A | ||||
| JP3517687B1 |
Other References:
【文献】米国特許3825538(US,A)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)