Title:
ステロール誘導体、及び形質転換した星状膠細胞に関係する疾患を治療するため、または悪性血液疾患を治療するためのその使用
Document Type and Number:
Japanese Patent JP2015520146
Kind Code:
A
Abstract:
本発明は、新規ステロール誘導体、その製造方法、それを含む医薬組成物、及び形質転換した星状膠細胞に関係する疾患を治療するため、または悪性血液疾患を治療するためのその使用に関する。本発明は、特に多形膠芽細胞腫及び他の癌、例えばリンパ腫、神経芽細胞腫及び黒色腫の治療に関する。
Inventors:
Clarion, Ludovic
Mersel, Marcel
Petite, Didier
Mersel, Marcel
Petite, Didier
Application Number:
JP2015510925A
Publication Date:
July 16, 2015
Filing Date:
May 07, 2013
Export Citation:
Assignee:
Beta Inobu
International Classes:
C07J9/00; A61K9/08; A61K9/10; A61K9/107; A61K9/127; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/575; A61K31/58; A61K47/10; A61K47/24; A61P35/00; A61P35/02; A61P43/00; C07J17/00
Other References:
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DUGAS,D. ET AL: "Synthesis of 7-dehydrocholesterol through a palladium catalyzed selective homoannular conjugated die", JOURNAL OF MOLECULAR CATALYSIS A: CHEMICAL, vol. Vol.253, No.1-2, JPN6017015165, 2006, pages 119 - 122, XP028015706, DOI: doi:10.1016/j.molcata.2006.03.014
C. W. SHOPPEE: "STEROIDS. PART XXX. SOME PROPERTIES OF THE CHOLEST-5-ENE-3β, 7-DIOLS AND THEIR ESTERS", JOURNAL OF THE CHEMICAL SOCIETY C: ORGANIC, JPN5015006401, 1 January 1968 (1968-01-01), pages 981 - 983
SELYE HANS: "CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS", ENDOCRINOLOGY, vol. V30, JPN5015006403, 1 January 1942 (1942-01-01), US, pages 37 - 453
JIA XIAN: "STUDIES ON THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF OXYSTEROL DERIVATIVES", ZHONGGUO YAOWU HUAXUE ZAZHI - CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. V15 N1, JPN5015006399, 1 January 2005 (2005-01-01), CN, pages 2 - 15
KIMURA,M. ET AL: "Metal ion-catalyzed oxidation of steroids. Part XIII. The reactions of cholesteryl acetate with te", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 29, no. 1, JPN6017015166, 1981, pages 35 - 42
DUGAS,D. ET AL: "Synthesis of 7-dehydrocholesterol through a palladium catalyzed selective homoannular conjugated die", JOURNAL OF MOLECULAR CATALYSIS A: CHEMICAL, vol. Vol.253, No.1-2, JPN6017015165, 2006, pages 119 - 122, XP028015706, DOI: doi:10.1016/j.molcata.2006.03.014
C. W. SHOPPEE: "STEROIDS. PART XXX. SOME PROPERTIES OF THE CHOLEST-5-ENE-3β, 7-DIOLS AND THEIR ESTERS", JOURNAL OF THE CHEMICAL SOCIETY C: ORGANIC, JPN5015006401, 1 January 1968 (1968-01-01), pages 981 - 983
SELYE HANS: "CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS", ENDOCRINOLOGY, vol. V30, JPN5015006403, 1 January 1942 (1942-01-01), US, pages 37 - 453
JIA XIAN: "STUDIES ON THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF OXYSTEROL DERIVATIVES", ZHONGGUO YAOWU HUAXUE ZAZHI - CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. V15 N1, JPN5015006399, 1 January 2005 (2005-01-01), CN, pages 2 - 15
KIMURA,M. ET AL: "Metal ion-catalyzed oxidation of steroids. Part XIII. The reactions of cholesteryl acetate with te", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 29, no. 1, JPN6017015166, 1981, pages 35 - 42
Attorney, Agent or Firm:
Kawaguchi International Patent Office