Title:
The use for treating malignant blood dyscrasia, in order to treat a sterol derivative and the disease related to the transformed astroglial cell
Document Type and Number:
Japanese Patent JP6270823
Kind Code:
B2
Abstract:
Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n; R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2); n : 1-3; R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3; R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6; R, R4 : H, 1-12C alkyl or optionally substituted aryl; R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR); R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR); B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR); R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8; and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I); and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.
Inventors:
Clarion, Ludovic
Mersel, Marcel
Petite, Didier
Mersel, Marcel
Petite, Didier
Application Number:
JP2015510925A
Publication Date:
January 31, 2018
Filing Date:
May 07, 2013
Export Citation:
Assignee:
Beta Inobu
International Classes:
C07J9/00; A61K9/08; A61K9/10; A61K9/107; A61K9/127; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/575; A61K31/58; A61K47/10; A61K47/24; A61P35/00; A61P35/02; A61P43/00; C07J17/00
Other References:
FIESER,L.F. et al,Cathylation (carbethoxylation) of steroid alcohols,Journal of the American Chemical Society,1952年,Vol.74,p.3309-13
DUGAS,D. et al,Synthesis of 7-dehydrocholesterol through a palladium catalyzed selective homoannular conjugated diene formation,Journal of Molecular Catalysis A: Chemical,2006年,Vol.253, No.1-2,p.119-122
C. W. SHOPPEE,STEROIDS. PART XXX. SOME PROPERTIES OF THE CHOLEST-5-ENE-3β, 7-DIOLS AND THEIR ESTERS,JOURNAL OF THE CHEMICAL SOCIETY C: ORGANIC,1968年 1月 1日,P.981-983
SELYE HANS,CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS,ENDOCRINOLOGY,米国,THE ENDOCRINE SOCIETY,1942年 1月 1日,V30,P437-453
JIA XIAN,STUDIES ON THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF OXYSTEROL DERIVATIVES,ZHONGGUO YAOWU HUAXUE ZAZHI - CHINESE JOURNAL OF MEDICINAL CHEMISTRY,中国,2005年 1月 1日,V15 N1,P12-15
KIMURA,M. et al,Metal ion-catalyzed oxidation of steroids. Part XIII. The reactions of cholesteryl acetate with tert-butyl hydroperoxide and molybdenum complexes,Chemical & Pharmaceutical Bulletin,1981年,Vol.29, No.1,p.35-42
DUGAS,D. et al,Synthesis of 7-dehydrocholesterol through a palladium catalyzed selective homoannular conjugated diene formation,Journal of Molecular Catalysis A: Chemical,2006年,Vol.253, No.1-2,p.119-122
C. W. SHOPPEE,STEROIDS. PART XXX. SOME PROPERTIES OF THE CHOLEST-5-ENE-3β, 7-DIOLS AND THEIR ESTERS,JOURNAL OF THE CHEMICAL SOCIETY C: ORGANIC,1968年 1月 1日,P.981-983
SELYE HANS,CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS,ENDOCRINOLOGY,米国,THE ENDOCRINE SOCIETY,1942年 1月 1日,V30,P437-453
JIA XIAN,STUDIES ON THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF OXYSTEROL DERIVATIVES,ZHONGGUO YAOWU HUAXUE ZAZHI - CHINESE JOURNAL OF MEDICINAL CHEMISTRY,中国,2005年 1月 1日,V15 N1,P12-15
KIMURA,M. et al,Metal ion-catalyzed oxidation of steroids. Part XIII. The reactions of cholesteryl acetate with tert-butyl hydroperoxide and molybdenum complexes,Chemical & Pharmaceutical Bulletin,1981年,Vol.29, No.1,p.35-42
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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