Title:
抗凝血剤として有用な大環状第VIIA因子阻害剤
Document Type and Number:
Japanese Patent JP5139999
Kind Code:
B2
Abstract:
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.
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Inventors:
E Scott Priestley
Daniel El Cheney
Nikola Ale Wurz
Peter W. Grants
Daniel El Cheney
Nikola Ale Wurz
Peter W. Grants
Application Number:
JP2008547767A
Publication Date:
February 06, 2013
Filing Date:
December 21, 2006
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/395; C07D245/04; C07D255/04; C07D273/02; C07D401/12; C07D413/12; C07D417/12; A61K31/4725; A61P7/02
Foreign References:
WO2003011222A1 | ||||
WO1999013063A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Samejima Mutsumi
Nagatoshi Shinagawa