VECTORS CONDITIONALLY EXPRESSING PROTEINS

Title:

VECTORS CONDITIONALLY EXPRESSING PROTEINS

Document Type and Number:

Japanese Patent JP2017212995

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide methods for inducing, regulating or enhancing erythropoietin expression in mammals.SOLUTION: Disclosed herein is a method comprising the steps of: (a) administering to a mammal an adeno-associated virus comprising a polynucleotide encoding EPO; (b) administering an activator ligand that induces EPO expression from the viral polynucleotide encoding EPO, where the adeno-associated virus is administered intramuscularly, the adeno-associated virus further comprises a gene switch where the gene switch comprises at least one transcription factor sequence operably linked to a promoter, at least one of the transcription factor is a ligand-dependent transcription factor, the adeno-associated virus further comprises a second promoter operably linked to the polynucleotide encoding EPO, and the second promoter is activated by the at least one ligand-dependent transcription factor following the administration of the activator ligand.SELECTED DRAWING: None

Inventors:

JEREMIAH F ROETH
CHARLES C REED
BRANDON CUTHBERTSON
SUNIL CHADA
WILLIAM E FOGLER
FAYAZ KHAZI

Application Number:

JP2017125428A

Publication Date:

December 07, 2017

Filing Date:

June 27, 2017

Export Citation:

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Assignee:

INTREXON CORP

International Classes:

C12N15/09; A01K67/027; A61K31/7088; A61K35/761; A61K48/00; A61P7/06; A61P43/00

Domestic Patent References:

JP2009545608A	2009-12-24
JP2009538283A	2009-11-05

Foreign References:

WO2009045370A2	2009-04-09
WO2010065792A2	2010-06-10
WO2010042189A2	2010-04-15
WO2009048560A1	2009-04-16

Attorney, Agent or Firm:

Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki

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