随伴不純物が低含有量であるオキサリプラチンおよびその調製方法

Japanese Patent JP2007508330

A

Oxaliplatin with a low content of accompanying impurities originating from its preparation which contains, by weight, at most 0.01%, preferably less than 0.001%, of alkali metals, at most 0.0005%, preferably less than 0.0002%, of silver, and at most 0.01%, preferably less than 0.001%, of nitrates. A method for preparation of the said oxaliplatin resides in that a suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N']platinum(II) in water is treated with silver nitrate, then, after removal of the solid phase, the obtained solution is treated with quaternary ammonium iodide of the formula (R)₄NI, the separated solid phase is removed and the obtained solution is treated with oxalic acid, and the separated oxaliplatin is isolated, washed with water and a polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture, and dried.

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Zaku, Frantisek
Tsuzaika-Pourova, Anna

JP2006534563A

April 05, 2007

October 14, 2004

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Privat-Rakema, A.S.

C07C51/41; C07C51/43; C07C55/06; C07C209/66; C07C211/36; C07F15/00

JPH05194332A	1993-08-03
JPS5331648A	1978-03-25
JPH05301884A	1993-11-16

Masao Okabe
Nobuaki Kato
Okabe
Shinichi Usui
Ikuo Fujino
Takao Ochi
Teruhisa Motomiya
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura

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