Title:
1, 3, 5-TRIAZINE DERIVATIVE AND METHOD OF USING SAME
Document Type and Number:
WIPO Patent Application WO/2017/016513
Kind Code:
A1
Abstract:
Disclosed are compounds having formulae I and II or pharmaceutically acceptable salts or hydrates thereof, a preparation method thereof and pharmaceutical compositions thereof. The compounds having formulae I and II possesses an isocitrate dehydrogenase 2 (IDH2) inhibitory activity and are capable of treating IDH2 mutation-induced cancers.
Inventors:
ZHAO NA (CN)
WANG SHULONG (CN)
LIU XIJIE (CN)
HU YUANDONG (CN)
ZHANG HUI (CN)
LUO HONG (CN)
PENG YONG (CN)
HAN YONGXIN (CN)
ZHANG XIQUAN (CN)
XU HONGJIANG (CN)
WANG SHULONG (CN)
LIU XIJIE (CN)
HU YUANDONG (CN)
ZHANG HUI (CN)
LUO HONG (CN)
PENG YONG (CN)
HAN YONGXIN (CN)
ZHANG XIQUAN (CN)
XU HONGJIANG (CN)
Application Number:
PCT/CN2016/092254
Publication Date:
February 02, 2017
Filing Date:
July 29, 2016
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
CENTAURUS BIOPHARMA CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
CENTAURUS BIOPHARMA CO LTD (CN)
International Classes:
A61K31/53; C07D251/18; A61P35/00; C07D251/26
Domestic Patent References:
| WO2015003360A2 | 2015-01-15 | |||
| WO2015017821A2 | 2015-02-05 |
Foreign References:
| BE618563A | 1962-12-14 | |||
| JPH04291336A | 1992-10-15 | |||
| CN104114543A | 2014-10-22 |
Other References:
TEDFORD, H.W. ET AL.: "In Silico Screening for Compounds that Match the Pharmacophore of Omega-Hexatoxin-Hv1a Leads to Discovery and Optimization of a Novel Class of Insecticides", PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol. 106, no. 3, 24 February 2013 (2013-02-24), pages 124 - 140, XP055350029
INOUE, Y. ET AL.: "Syntheses of Phenylazo-1,3,5-Triazines by the Oxidative Coupling of Hydrazino-1,3,5-Triazines with N,N-Disubstituted Anilines", CHEMISTRY LETTERS, vol. 10, no. 12, 31 December 1981 (1981-12-31), pages 1733 - 1736, XP055350031
INOUE, Y. ET AL.: "Syntheses of Phenylazo-1,3,5-Triazines by the Oxidative Coupling of Hydrazino-1,3,5-Triazines with N,N-Disubstituted Anilines", CHEMISTRY LETTERS, vol. 10, no. 12, 31 December 1981 (1981-12-31), pages 1733 - 1736, XP055350031
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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