1-AMINO-2-VINYL CYCLOPROPANE CARBOXYLIC ACID AMIDE, SALT OF SAME, AND METHOD FOR PRODUCING SAME

WIPO Patent Application WO/2012/176715

A1

The present invention relates to a 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof. By obtaining an optically active 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof by hydrolyzing an optically active 1-amino-2-vinyl cyclopropane carbonitrile or a salt thereof by the production method of the present invention, a 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof which is useful as a pharmaceutical/agrochemical intermediate can be easily obtained. The present invention is capable of providing a substrate to be subjected to optical resolution, said substrate enabling the production of an optically active 1-amino-2-vinyl cyclopropane carboxylic acid, which is widely used as a starting material for pharmaceutical and agrochemical products and is especially important as an intermediate for therapeutic agents for hepatitis C, with high purity and high yield at low cost.

MATSUMOTO MASAHIRO (JP)

PCT/JP2012/065452

December 27, 2012

June 18, 2012

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MITSUBISHI GAS CHEMICAL CO (JP)
MATSUMOTO MASAHIRO (JP)

C07C237/24; C07C227/18; C07C227/30; C07C229/48; C07C231/06; C07C231/16; C12P13/02; C07B53/00

WO2008070358A2	2008-06-12
WO2010041739A1	2010-04-15
WO2007088571A2	2007-08-09
WO2000009543A2	2000-02-24

US20110135599A1	2011-06-09
JP2009536158A	2009-10-08
JP2007516981A	2007-06-28
EP2345633A1	2011-07-20
JP2010043124A	2010-02-25

DRUGS OF THE FUTURE, vol. 34, no. 7, 2009, pages 545
ORGANIC RESEARCH & DEVELOPMENT, vol. 14, 2010, pages 692
J. ORG. CHEM., vol. 64, no. 13, 1999, pages 4712

KATSUNUMA Hirohito et al. (JP)
Katsunuma Hirohito (JP)

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