Title:
1-CARBOXY-1-VYNILOXYIMINOAMINOTHIAZOLE CEPHALOSPORING DERIVATIVES AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/1987/006232
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group, an azido group, an optionally substituted quaternary ammonio group, or an optionally substituted 5- or 6-membered aromatic heterocyclic thio group containing at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom (additionally, the aromatic hetero ring being optionally bound to a benzene ring or a hetero cyclic ring)], nontoxic salts thereof or nontoxic esters thereof capable of being physiologically hydrolized, process for their preparation, and antibacterial agent containing the compound as an effective ingredient. Further, compounds represented by general formula (III), (wherein R3 represents a hydrogen atom or an amino protective group, and R4 and R5, which may be the same or different, each represents a hydrogen atom or a carboxyl protective group) or their salts and process for their preparation.
Inventors:
NAKAGAWA SUSUMU (JP)
MITOMO RYUJI (JP)
YAMADA KOJI (JP)
OTAKE NORIKAZU (JP)
NAKANO FUMIO (JP)
ASAI AKIRA (JP)
KUROYANAGI SATORU (JP)
TANAKA YOSHIHARU (JP)
ISHIKAWA MORIAKI (JP)
USHIJIMA RYOSUKE (JP)
MITOMO RYUJI (JP)
YAMADA KOJI (JP)
OTAKE NORIKAZU (JP)
NAKANO FUMIO (JP)
ASAI AKIRA (JP)
KUROYANAGI SATORU (JP)
TANAKA YOSHIHARU (JP)
ISHIKAWA MORIAKI (JP)
USHIJIMA RYOSUKE (JP)
Application Number:
PCT/JP1987/000236
Publication Date:
October 22, 1987
Filing Date:
April 14, 1987
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
International Classes:
A61K31/545; C07D235/28; C07D263/46; C07D263/58; C07D271/113; C07D277/20; C07D277/36; C07D277/40; C07D277/56; C07D285/125; C07D501/22; C07D501/24; C07D501/34; C07D501/36; C07D501/46; C07D271/10; C07D285/12; (IPC1-7): C07D501/22; C07D501/24; C07D501/34; C07D501/36; C07D501/46; C07D277/40; A61K31/545
Foreign References:
| JPS57131794A | 1982-08-14 | |||
| JPS54154788A | 1979-12-06 | |||
| EP0153709A2 | 1985-09-04 | |||
| DE3019462A1 | 1980-12-04 | |||
| US4196205A | 1980-04-01 | |||
| JPS61254584A | 1986-11-12 |
Other References:
See also references of EP 0346465A4
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