Title:
scsCNTFR/NNT-1 FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO2001055219
Kind Code:
A3
Abstract:
The invention concerns a scsCNTFR/NNT-1 fusion protein comprising a NNT-1 protein, a sCNTFR alpha protein and a binding element which binds said two proteins. The invention also concerns a composition comprising said fusion protein as medicine for preventing and/or treating neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson's disease or Huntington's disease, for maintaining muscle mass in paralyzed persons, for treating obesity or cancer.
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Inventors:
ELSON GREG (FR)
GAUCHAT JEAN-FRANCOIS (FR)
GAUCHAT JEAN-FRANCOIS (FR)
Application Number:
PCT/FR2001/000254
Publication Date:
March 07, 2002
Filing Date:
January 26, 2001
Export Citation:
Assignee:
PF MEDICAMENT (FR)
ELSON GREG (FR)
GAUCHAT JEAN FRANCOIS (FR)
ELSON GREG (FR)
GAUCHAT JEAN FRANCOIS (FR)
International Classes:
A61P1/00; A61P3/00; A61P3/04; A61P7/00; A61P15/00; A61P19/00; A61P21/00; A61P25/00; A61P27/00; A61P35/00; A61P37/00; C07K14/52; C07K14/71; C07K14/715; A61K38/00; (IPC1-7): C07K14/715; A61K38/19; A61P25/00; A61P35/00; C07K14/52; C07K16/24; C12N15/19; C12N15/63; G01N33/68
Domestic Patent References:
| WO1998033922A1 | 1998-08-06 | |||
| WO1999000415A1 | 1999-01-07 |
Other References:
SENALDI GIORGIO ET AL: "Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES,US,NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 96, no. 20, September 1999 (1999-09-01), pages 11458 - 11463, XP002144214, ISSN: 0027-8424
MARCO DI A ET AL: "AGONISTIC AND ANTAGONISTIC VARIANTS OF CILIARY NEUROTROPHIC FACTOR (CNTF) REVEAL FUNCTIONAL DIFFERENCES BETWEEN MEMBRANE-BOUND AND SOLUBLE CNTF ALPHA-RECEPTOR", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23069 - 23075, XP002069814, ISSN: 0021-9258
FISCHER M ET AL: "A BIOACTIVE DESIGNER CYTOKINE FOR HUMAN HEMATOPOIETIC PROGENITOR CELL EXPANSION", NATURE BIOTECHNOLOGY,US,NATURE PUBLISHING, vol. 15, no. 2, 1 February 1997 (1997-02-01), pages 142 - 145, XP002047603, ISSN: 1087-0156
LIMING S CHEN-F ET AL: "Generation and characterization of a single-gene encoded single-chain immunoglobulin-interleukin-2 fusion protein", IMMUNOTECHNOLOGY,NL,ELSEVIER SCIENCE PUBLISHERS BV, vol. 1, no. 3, 1 December 1995 (1995-12-01), pages 231 - 241, XP004052725, ISSN: 1380-2933
MARCO DI A ET AL: "AGONISTIC AND ANTAGONISTIC VARIANTS OF CILIARY NEUROTROPHIC FACTOR (CNTF) REVEAL FUNCTIONAL DIFFERENCES BETWEEN MEMBRANE-BOUND AND SOLUBLE CNTF ALPHA-RECEPTOR", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23069 - 23075, XP002069814, ISSN: 0021-9258
FISCHER M ET AL: "A BIOACTIVE DESIGNER CYTOKINE FOR HUMAN HEMATOPOIETIC PROGENITOR CELL EXPANSION", NATURE BIOTECHNOLOGY,US,NATURE PUBLISHING, vol. 15, no. 2, 1 February 1997 (1997-02-01), pages 142 - 145, XP002047603, ISSN: 1087-0156
LIMING S CHEN-F ET AL: "Generation and characterization of a single-gene encoded single-chain immunoglobulin-interleukin-2 fusion protein", IMMUNOTECHNOLOGY,NL,ELSEVIER SCIENCE PUBLISHERS BV, vol. 1, no. 3, 1 December 1995 (1995-12-01), pages 231 - 241, XP004052725, ISSN: 1380-2933
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