Title:
1-INDANE DERIVATIVE HAVING ANTI-PROTOZOAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2014/076965
Kind Code:
A1
Abstract:
The present invention provides: an inhibitor of the proliferation of a human-infecting malaria-causing protozoa and a human-infecting protozoa of the genus trypanosome; and a therapeutic agent and a prophylactic agent. Specifically, a pharmaceutical composition having a prophylactic or therapeutic effect on infections caused by a malaria-causing protozoa and a protozoa of the genus trypanosome, said pharmaceutical composition comprising a compound represented by general formula (I) and a pharmacologically acceptable salt thereof as active ingredients.
[In the formula, R1 to R4 independently represent a hydrogen atom, a C1-8 alkyl group, a C2-8 alkenyl group, a C6-10 aryl group, a C1-8 alkoxy group, a C1-8 alkylthio group, a hydroxy group, a halogen atom or an amino group (wherein a case in which each of R1 to R4 represents a hydroxy group is excluded); and R5 and R6 independently represent a hydroxy group or a group -SO3Na, or R5 and R6 together form an oxo group or a group =N-R7.]
Inventors:
OMURA SATOSHI (JP)
OTOGURO KAZUHIKO (JP)
IWATSUKI MASATO (JP)
ISHIYAMA AKI (JP)
OTAKI YOSHIHIRO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
OTOGURO KAZUHIKO (JP)
IWATSUKI MASATO (JP)
ISHIYAMA AKI (JP)
OTAKI YOSHIHIRO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
Application Number:
PCT/JP2013/006722
Publication Date:
May 22, 2014
Filing Date:
November 15, 2013
Export Citation:
Assignee:
KITASATO INST (JP)
BIOFRONTIER PARTNERS INC (JP)
BIOFRONTIER PARTNERS INC (JP)
International Classes:
A61K31/445; A61P33/02; A61P33/06; C07D211/24; C07D211/28
Domestic Patent References:
| WO2010019560A1 | 2010-02-18 |
Foreign References:
| US4895841A | 1990-01-23 |
Other References:
LIM, L. Y. ET AL.: "The anticholinesterase activity of mefloquine", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 12, no. 5, 1985, pages 527 - 531, XP000900059
LENTA, B. N. ET AL.: "Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 56, no. 2, 2008, pages 222 - 226
DEVKOTA, K. P. ET AL.: "Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 59, no. 9, 2007, pages 1397 - 1401
MCARDLE, J. J. ET AL.: "Mefloquine inhibits cholinesterases at the mouse neuromuscular junction", NEUROPHARMACOLOGY, vol. 49, no. 8, 2005, pages 1132 - 1139, XP005160054, DOI: doi:10.1016/j.neuropharm.2005.06.011
DE ANDRASE, J. P . ET AL.: "Bioactive alkaloid extracts from Narcissus broussonetii: Mass spectral studies", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 70, 12 May 2012 (2012-05-12), pages 13 - 25
LENTA, B. N. ET AL.: "Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 56, no. 2, 2008, pages 222 - 226
DEVKOTA, K. P. ET AL.: "Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 59, no. 9, 2007, pages 1397 - 1401
MCARDLE, J. J. ET AL.: "Mefloquine inhibits cholinesterases at the mouse neuromuscular junction", NEUROPHARMACOLOGY, vol. 49, no. 8, 2005, pages 1132 - 1139, XP005160054, DOI: doi:10.1016/j.neuropharm.2005.06.011
DE ANDRASE, J. P . ET AL.: "Bioactive alkaloid extracts from Narcissus broussonetii: Mass spectral studies", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 70, 12 May 2012 (2012-05-12), pages 13 - 25
Attorney, Agent or Firm:
HASEGAWA, Hiroshi et al. (JP)
Hiroshi Hasegawa (JP)
Hiroshi Hasegawa (JP)
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