Title:
1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO2003097649
Kind Code:
A3
Abstract:
The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-cc (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
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Inventors:
MERCEP MLADEN (HR)
MESIC MILAN (HR)
PESIC DIJANA (HR)
MESIC MILAN (HR)
PESIC DIJANA (HR)
Application Number:
PCT/HR2003/000024
Publication Date:
April 29, 2004
Filing Date:
May 20, 2003
Export Citation:
Assignee:
PLIVA D D (HR)
MERCEP MLADEN (HR)
MESIC MILAN (HR)
PESIC DIJANA (HR)
MERCEP MLADEN (HR)
MESIC MILAN (HR)
PESIC DIJANA (HR)
International Classes:
A61K31/335; A61K31/34; A61K31/343; A61K31/38; A61K31/55; A61P1/00; A61P1/04; A61P11/06; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D307/00; C07D313/00; C07D403/04; C07D493/02; C07D493/04; C07D495/02; C07D497/02; (IPC1-7): C07D493/04; A61K31/55
Domestic Patent References:
| WO2001087890A1 | 2001-11-22 | |||
| WO1999000355A1 | 1999-01-07 |
Foreign References:
| US4198421A | 1980-04-15 |
Other References:
WERMUTH ET AL: "The Practise of Medicinal Chemistry", PRACTICE OF MEDICINAL CHEMISTRY, XX, XX, 1996, pages 203 - 237, XP002190259
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