Title:
11C-LABELLED PEPTIDE FOR DETECTING AN ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2012/000841
Kind Code:
A3
Abstract:
There is described the use of a peptide (1) for the preparation of an agent for detecting an antibody (4), where the peptide (1) binds to a paratope (5) of the antibody (4) and includes an 11C carbon atom. Also provided is a radiopharmaceutical for locating a tumour (18) comprising a peptide (1) which includes an 11C carbon atom, where the peptide (1) binds to a paratope (5) of an antibody (4) which is directed against the tumour (18).
Inventors:
KOLB HARTMUTH (US)
LADE OLIVER (DE)
PRZYBYLSKI MICHAEL (DE)
KRUEGER URSUS (DE)
MANEA MARILENA (DE)
STECKENBORN ARNO (DE)
LADE OLIVER (DE)
PRZYBYLSKI MICHAEL (DE)
KRUEGER URSUS (DE)
MANEA MARILENA (DE)
STECKENBORN ARNO (DE)
Application Number:
PCT/EP2011/060350
Publication Date:
March 08, 2012
Filing Date:
June 21, 2011
Export Citation:
Assignee:
SIEMENS AG (DE)
UNIV KONSTANZ (DE)
KOLB HARTMUTH (US)
LADE OLIVER (DE)
PRZYBYLSKI MICHAEL (DE)
KRUEGER URSUS (DE)
MANEA MARILENA (DE)
STECKENBORN ARNO (DE)
UNIV KONSTANZ (DE)
KOLB HARTMUTH (US)
LADE OLIVER (DE)
PRZYBYLSKI MICHAEL (DE)
KRUEGER URSUS (DE)
MANEA MARILENA (DE)
STECKENBORN ARNO (DE)
International Classes:
A61K51/08
Domestic Patent References:
| WO2011012414A1 | 2011-02-03 |
Other References:
R. SCHOFFELEN ET AL: "Pretargeted Immuno-Positron Emission Tomography Imaging of Carcinoembryonic Antigen-Expressing Tumors with a Bispecific Antibody and a 68Ga- and 18F-Labeled Hapten Peptide in Mice with Human Tumor Xenografts", MOLECULAR CANCER THERAPEUTICS, vol. 9, no. 4, 1 April 2010 (2010-04-01), pages 1019 - 1027, XP055016111, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-09-0862
HENRIKSEN G ET AL: "Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER VERLAG, HEIDELBERG, DE, vol. 31, no. 12, 10 August 2004 (2004-08-10), pages 1653 - 1657, XP002383248, ISSN: 1619-7070, DOI: 10.1007/S00259-004-1582-1
SANDELL J ET AL: "Labelling of a cholecystokinin (CCK) peptide with 11C, and examination of its brain uptake in a cynomolgus monkey with PET", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 40, 1 December 1997 (1997-12-01), pages 771 - 773, XP002663002, ISSN: 0362-4803
SCHIRRMACHER R ET AL: "Rapid in situ synthesis of [<11>C]methyl azide and its application in <11>C click-chemistry", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 33, 11 August 2008 (2008-08-11), pages 4824 - 4827, XP022819091, ISSN: 0040-4039, [retrieved on 20080610], DOI: 10.1016/J.TETLET.2008.06.020
HENRIKSEN G ET AL: "Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER VERLAG, HEIDELBERG, DE, vol. 31, no. 12, 10 August 2004 (2004-08-10), pages 1653 - 1657, XP002383248, ISSN: 1619-7070, DOI: 10.1007/S00259-004-1582-1
SANDELL J ET AL: "Labelling of a cholecystokinin (CCK) peptide with 11C, and examination of its brain uptake in a cynomolgus monkey with PET", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 40, 1 December 1997 (1997-12-01), pages 771 - 773, XP002663002, ISSN: 0362-4803
SCHIRRMACHER R ET AL: "Rapid in situ synthesis of [<11>C]methyl azide and its application in <11>C click-chemistry", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 33, 11 August 2008 (2008-08-11), pages 4824 - 4827, XP022819091, ISSN: 0040-4039, [retrieved on 20080610], DOI: 10.1016/J.TETLET.2008.06.020
Attorney, Agent or Firm:
ELBEL, Michaela (Altheimer Eck 13, München, DE)
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