Title:
1,2-ANNELATED QUINOLINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2000039082
Kind Code:
A3
Abstract:
This invention concerns compounds of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein =X<1>-X<2>-X<3>- is a trivalent radical; >Y<1>-Y<2>- is a trivalent radical; r and s are each independently 0, 1, 2, 3, 4 or 5; t is 0, 1, 2 or 3; each R<1> and R<2> are independently hydroxy, halo, cyano, C1-6alkyl, trihalomethyl, trihalomethoxy, C2-6alkenyl, C1-6alkyloxy, hydroxyC1-6alkyloxy, C1-6alkylthio, C1-6alkyloxyC1-6alkyloxy, C1-6alkyloxycarbonyl, aminoC1-6alkyloxy, mono- or di(C1-6alkyl)amino, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, aryl, arylC1-6alkyl, aryloxy or arylC1-6alkyloxy, hydroxycarbonyl, C1-6alkyloxycarbonyl; or two R<1> or R<2> on adjacent positions form together a bivalent radical; R<3> is hydrogen, halo, C1-6alkyl, cyano, haloC1-6alkyl, hydroxyC1-6alkyl, cyanoC1-6alkyl, aminoC1-6alkyl, C1-6alkyloxyC1-6alkyl, C1-6alkylthio-C1-6alkyl, aminocarbonylC1-6alkyl, hydroxycarbonyl, hydroxycarbonylC1-6alkyl, C1-6alkyloxycarbonylC1-6alkyl, C1-6alkylcarbonylC1-6alkyl, C1-6alkyloxycarbonyl, aryl, arylC1-6alkyloxyC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, or a radical of formula -O-R<10>, -S-R<10> or -NR<11>R<12>; R<4> is an optionally substituted imidazolyl; aryl is an optionally substituted phenyl or naphthalenyl; having farnesyl transferase and geranylgeranyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
Inventors:
ANGIBAUD PATRICK RENE (FR)
VENET MARC GASTON (FR)
BOURDREZ XAVIER MARC (FR)
VENET MARC GASTON (FR)
BOURDREZ XAVIER MARC (FR)
Application Number:
PCT/EP1999/010214
Publication Date:
October 26, 2000
Filing Date:
December 17, 1999
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
ANGIBAUD PATRICK RENE (FR)
VENET MARC GASTON (FR)
BOURDREZ XAVIER MARC (FR)
ANGIBAUD PATRICK RENE (FR)
VENET MARC GASTON (FR)
BOURDREZ XAVIER MARC (FR)
International Classes:
A61K31/4365; A61K31/4709; A61K31/4745; A61K31/498; A61K31/519; A61P35/00; C07D215/18; C07D401/06; C07D403/06; C07D471/04; C07D487/04; C07D215/06; (IPC1-7): C07D471/04; C07D487/04; A61K31/4365; A61K31/519; A61P35/00; C07D401/06; C07D403/06
Domestic Patent References:
| WO1997016443A1 | 1997-05-09 | |||
| WO1997021701A1 | 1997-06-19 | |||
| WO1998049157A1 | 1998-11-05 |
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