12-DEOXYFUSICOCCIN SUGAR CHAIN-MODIFIED DERIVATIVES AND USES THEREOF

Title:

12-DEOXYFUSICOCCIN SUGAR CHAIN-MODIFIED DERIVATIVES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2010/090234

Kind Code:

A1

Abstract:

Disclosed are novel water-soluble compounds that have differentiation-inducing effects on mammalian cells, cell differentiation-inducing agents that have said compounds as active ingredients and anti-tumor agents. Disclosed are compounds and salts thereof that are represented by general formula (1) (1) (wherein n represents an integer 0‑5, Me a methyl group, and R1 a 1- to 6-carbon alkyl group or amino group represented by formula (2) (2) (wherein R2 represents a hydrogen atom or 1- to 6-carbon alkyl group, R3 a hydrogen atom, 1- to 6-carbon alkyl group, a 1- to 7-carbon acyl group or amidyl group (–CNHNH2)])

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Inventors:

KATO NOBUO (JP)
INOUE TAKATSUGU (JP)
MARUYAMA YURIKO (JP)
NITTA HAJIME (JP)
HONMA YOSHIO (JP)
SASSA TAKESHI (JP)

Application Number:

PCT/JP2010/051537

Publication Date:

August 12, 2010

Filing Date:

February 03, 2010

Export Citation:

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Assignee:

UNIV OSAKA (JP)
NAT UNIVERSITY CORP SHIMANE UN (JP)
KATO NOBUO (JP)
INOUE TAKATSUGU (JP)
MARUYAMA YURIKO (JP)
NITTA HAJIME (JP)
HONMA YOSHIO (JP)
SASSA TAKESHI (JP)

International Classes:

C07D493/04; A61K31/34; A61P35/00

Domestic Patent References:

WO2008010324A1

2008-01-24

Other References:

KASSOU, M. ET AL.: "Ring Contraction vs Fragmentation in the Intramolecular Reactions of 3-0-(Trifluoromethanesulfonyl)pyranosides. Efficient Synthesis of Branched-Chain Furanosides", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 14, 1995, pages 4353 - 4358

Attorney, Agent or Firm:

SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)

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