Title:
1,2,4- THIADIAZOL-5-THIO COMPOUNDS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF AS UREASE AND NITRIFICATION INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005007636
Kind Code:
B1
Abstract:
The invention relates to methods for the production and use of novel 1,2,4-thiadiazols of general formulae (I) or (II) as agents for regulating the inhibition of enzymatic urea hydrolysis, wherein R<1> = hydrogen, C1-C8-alkyl or C6-C10-aryl and R<2> = hydrogen, C1-C8- alkyl/heteroalkyl, C2-C8 -alkenyl/heteroalkenyl, C2-C8 -alkinyl/heteroalkinyl, C3-C8- cycloalkyl/heterocycloalkyl, C3-C8 -cycloalkenyl/heterocycloalkenyl, C6-C10 -aryl/heteroaryl, aralkyl, heteroarylalkyl, alkaryl, akheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, amino, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, fluorine, chlorine, bromine, iodine, hydroxy, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, the radicals R<1> and/or R<2> can, optionally, be per se and individually substituted by one or several of the above-mentioned groups. With a limited spectrum of substituents in R<2>, said compounds can be claimed as nitrification inhibitors. The inventive 1,2,4-thiadiazols thus used are effective urease inhibitors and have a good resistance to hydrolysis and can be produced according to known methods. They are also effective nitrification inhibitors and can delay transformation of ammonia. They are the first inhibitors which effectively eliminate the two main sources of loss during the application of manure, i.e. urease-catalyzed urea hydrolysis and nitrification of ammonia nitrogen. The inventive compounds can also be combined with more potent nitrification inhibitors, whereby nitrogen losses can also be reduced, without any problem.
Inventors:
PALMER THOMAS (DE)
NICLAS HANS-JOACHIM (DE)
SCHUSTER CAROLA (DE)
MICHEL HANS-JUERGEN (DE)
GRABARSE MARGRIT (DE)
HUCKE ANDRE (DE)
NICLAS HANS-JOACHIM (DE)
SCHUSTER CAROLA (DE)
MICHEL HANS-JUERGEN (DE)
GRABARSE MARGRIT (DE)
HUCKE ANDRE (DE)
Application Number:
PCT/EP2004/006269
Publication Date:
April 07, 2005
Filing Date:
June 09, 2004
Export Citation:
Assignee:
PIESTERITZ STICKSTOFF (DE)
PALMER THOMAS (DE)
NICLAS HANS-JOACHIM (DE)
SCHUSTER CAROLA (DE)
MICHEL HANS-JUERGEN (DE)
GRABARSE MARGRIT (DE)
HUCKE ANDRE (DE)
PALMER THOMAS (DE)
NICLAS HANS-JOACHIM (DE)
SCHUSTER CAROLA (DE)
MICHEL HANS-JUERGEN (DE)
GRABARSE MARGRIT (DE)
HUCKE ANDRE (DE)
International Classes:
C05G3/90; C07D285/08; (IPC1-7): C07D285/08
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