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Title:
1,2,4-TRIAZOLE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177752
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicine, and specifically disclosed thereby are a 1,2,4-triazole compound represented by formula (I) and a physiologically acceptable salt thereof, a preparation method for the compound, a pharmaceutical preparation containing the compound, and an application of the compound in the preparation of drugs for the prevention and treatment of diseases associated with hyperuricemia.

Inventors:
XIAO ZHIYAN (CN)
YE FEI (CN)
YANG YAJUN (CN)
TIAN JINYING (CN)
YAN DINGAN (CN)
ZHANG XIAOLIN (CN)
YANG YING (CN)
LI XUECHEN (CN)
REN LONG (CN)
YAN ZHENXIN (CN)
HOU XIANXIN (CN)
JIANG NAN (CN)
NAN GUANGLEI (CN)
Application Number:
PCT/CN2020/078082
Publication Date:
September 10, 2020
Filing Date:
March 05, 2020
Export Citation:
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Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07D401/04; A61K31/4196; A61K31/4439; A61K31/4709; A61K31/506; A61P19/06; C07D249/08; C07D403/04; C07D405/04; C07D409/04; C07D417/04
Domestic Patent References:
WO1997005878A11997-02-20
Foreign References:
JP2008088107A2008-04-17
US3892762A1975-07-01
CN103210084A2013-07-17
Other References:
陆海波等 (LU, HAIBO ET AL.): "高尿酸血症治疗药物黄嘌呤氧化酶抑制剂的研究进展 (Research Process of Xanthine Oxidase Inhibitors as Hyperuricemia Drug)", 安徽医药 (ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL), vol. 20, no. 4, 30 April 2016 (2016-04-30), XP55731696, DOI: 20200604105243A
SATO, T. ET AL.: "Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1, 2, 4-triazole derivatives as xanthine oxidoreductase inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 1, 5 November 2008 (2008-11-05), XP025816902, DOI: 20200604152911
BALDWIN, J. J. ET AL.: "4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1, 2, 4-triazoles, new classes of xanthine oxidase inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 18, no. 9, 1 September 1975 (1975-09-01), XP002670056, DOI: 20200604160348A
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