[1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-2-YLUREA DERIVATIVE AND USE THEREOF

Title:

[1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-2-YLUREA DERIVATIVE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2004/108729

Kind Code:

A1

Abstract:

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.

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Inventors:

MASUDA AKIRA (JP)
SATOH YOSHITAKA (JP)
AKIYAMA YUJI (JP)
SAIGA KAN (JP)
TOYODA ERIKO (JP)

Application Number:

PCT/JP2004/007623

Publication Date:

December 16, 2004

Filing Date:

June 02, 2004

Export Citation:

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Assignee:

NIPPON KAYAKU KK (JP)
MASUDA AKIRA (JP)
SATOH YOSHITAKA (JP)
AKIYAMA YUJI (JP)
SAIGA KAN (JP)
TOYODA ERIKO (JP)

International Classes:

A61K31/519; A61K31/5377; A61P1/00; A61P1/04; A61P3/10; A61P7/04; A61P7/06; A61P11/06; A61P13/12; A61P17/00; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/519; A61K31/5377; A61P1/00; A61P1/04; A61P3/10; A61P7/04; A61P7/06; A61P11/06; A61P13/12; A61P17/00; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00

Domestic Patent References:

WO1992010098A1

1992-06-25

Foreign References:

US5484760A	1996-01-16
JPS62108882A	1987-05-20

Other References: