Title:
1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2012/173447
Kind Code:
A2
Abstract:
The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as: polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.
Inventors:
JUNG YOUNG SIK (KR)
LEE CHONG KGO (KR)
CHOI IHL YOUNG (KR)
KIM HAE SOO (KR)
KIM PIL HO (KR)
HAN SOO BONG (KR)
NEYTS JOHAN (BE)
THIBAUT HENDRIK JAN (BE)
LEE CHONG KGO (KR)
CHOI IHL YOUNG (KR)
KIM HAE SOO (KR)
KIM PIL HO (KR)
HAN SOO BONG (KR)
NEYTS JOHAN (BE)
THIBAUT HENDRIK JAN (BE)
Application Number:
PCT/KR2012/004804
Publication Date:
December 20, 2012
Filing Date:
June 18, 2012
Export Citation:
Assignee:
KOREA RES INST CHEM TECH (KR)
UNIV LEUVEN KATH (BE)
JUNG YOUNG SIK (KR)
LEE CHONG KGO (KR)
CHOI IHL YOUNG (KR)
KIM HAE SOO (KR)
KIM PIL HO (KR)
HAN SOO BONG (KR)
NEYTS JOHAN (BE)
THIBAUT HENDRIK JAN (BE)
UNIV LEUVEN KATH (BE)
JUNG YOUNG SIK (KR)
LEE CHONG KGO (KR)
CHOI IHL YOUNG (KR)
KIM HAE SOO (KR)
KIM PIL HO (KR)
HAN SOO BONG (KR)
NEYTS JOHAN (BE)
THIBAUT HENDRIK JAN (BE)
International Classes:
C07C13/465; A61K31/04; A61K31/47; A61P31/12
Foreign References:
| US4569945A | 1986-02-11 |
Other References:
HEINZ B A; VANCE L M, J VIROL, vol. 69, no. 7, 1995, pages 4189 - 97
MILLER FD ET AL., ANTIMICROB AGENTS CHEMOTHER, vol. 27, no. 1, 1985, pages 102 - 6
PATTICK A K ET AL., ANTIMICROBILA AGENTS CHEMOTHER, vol. 43, no. 10, 1999, pages 2444 - 50
DIANA G D, CURR MED CHEM, vol. 2, 2003, pages 1 - 12
PEVEAR D C ET AL., ANTIMICROB AGENTS CHEMOTHER, vol. 43, no. 9, 1999, pages 2109 - 15
MCKINLAY M A ET AL., ANNU REV MICROBIOL, vol. 46, 1992, pages 635 - 54
LEDFORD R M ET AL., J VIROL, vol. 78, no. 7, 2004, pages 3663 - 74
GROARKE J M ET AL., J INFECT DIS, vol. 179, no. 6, 1999, pages 1538 - 41
RYAN, J. ET AL., ANTIVIRAL RES [18TH INTL CONF ANTIVIRAL RES, vol. 65, no. 3, 11 April 2005 (2005-04-11)
See also references of EP 2722322A4
MILLER FD ET AL., ANTIMICROB AGENTS CHEMOTHER, vol. 27, no. 1, 1985, pages 102 - 6
PATTICK A K ET AL., ANTIMICROBILA AGENTS CHEMOTHER, vol. 43, no. 10, 1999, pages 2444 - 50
DIANA G D, CURR MED CHEM, vol. 2, 2003, pages 1 - 12
PEVEAR D C ET AL., ANTIMICROB AGENTS CHEMOTHER, vol. 43, no. 9, 1999, pages 2109 - 15
MCKINLAY M A ET AL., ANNU REV MICROBIOL, vol. 46, 1992, pages 635 - 54
LEDFORD R M ET AL., J VIROL, vol. 78, no. 7, 2004, pages 3663 - 74
GROARKE J M ET AL., J INFECT DIS, vol. 179, no. 6, 1999, pages 1538 - 41
RYAN, J. ET AL., ANTIVIRAL RES [18TH INTL CONF ANTIVIRAL RES, vol. 65, no. 3, 11 April 2005 (2005-04-11)
See also references of EP 2722322A4
Attorney, Agent or Firm:
LEE, Won Hee (642-16 Yoksam-dong,Kangnam-ku, Seoul 135-080, KR)
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Claims: