Title:
13-OXIDIZED INGENOL DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/224007
Kind Code:
A1
Abstract:
The present invention relates to a derivative of 13-oxidized ingenol, the use thereof in the prevention and/or treatment of diseases associated with proliferation or tumours in a subject, or cosmetic indications, and the use thereof in the prevention and/or treatment of a disease responsive to an oxidative burst of neutrophilic granulocytes, a disease responsive to a release of IL-8 by keratinocytes, or a disease responsive to induced necrosis.
Inventors:
WU XIAO (CN)
PAN QIN (CN)
LI YANYUN (CN)
YANG YU (CN)
GUAN YUZHEN (CN)
WU XIAOLEI (CN)
SUN CHUANTENG (CN)
WANG YUAN (CN)
PAN QIN (CN)
LI YANYUN (CN)
YANG YU (CN)
GUAN YUZHEN (CN)
WU XIAOLEI (CN)
SUN CHUANTENG (CN)
WANG YUAN (CN)
Application Number:
PCT/CN2018/090272
Publication Date:
December 13, 2018
Filing Date:
June 07, 2018
Export Citation:
Assignee:
R & D CENTER OF TIANJIN ZHONGXIN PHARMACEUTICALS (CN)
International Classes:
C07C69/33; A61K31/215; A61P35/00
Foreign References:
| JPH08245505A | 1996-09-24 | |||
| JPH08245379A | 1996-09-24 |
Other References:
OHYOSHI, T. ET AL.: "Total Synthesis of Natural Derivatives and Artificial Analogs of 13- Oxyingenol and Their Biological Evaluation", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 48, 14 November 2016 (2016-11-14), pages 11426 - 11437, XP055551149
WANG HY ET AL., PHYTOTHERAPY RESEARCH, vol. 26, no. 6, 2012, pages 853 - 9
ABREU CM ET AL., PLOS ONE, vol. 9, no. 5, 2014, pages e97257
ASADA A. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 43, 1998, pages 28392 - 28398
ZHAO XUEYAN ET AL., CHINESE HERBAL MEDICINE, vol. 45, no. 20, 2014, pages 3029 - 3033
WANG HY ET AL., PHYTOTHERAPY RESEARCH, vol. 26, no. 6, 2012, pages 853 - 859
WU TS ET AL., JOURNAL OF NATURAL PRODUCTS, vol. 54, no. 3, 1991, pages 823 - 829
KHIEV PET, ARCHIVES PHARMACAL RESEARCH, vol. 35, no. 9, 2012, pages 1553 - 1558
ROSEN RH ET AL., JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 66, no. 3, 2012, pages 486 - 493
OGBOURNE S. M. ET AL., CANCER RESEARCH, vol. 64, 2004, pages 2833 - 2839
HAMPSON P. ET AL., CANCER IMMUNOL IMMUNOTHER, vol. 57, 2008, pages 1241 - 1251
CHALLACOMBE JM ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 177, 2006, pages 8123 - 8132
WANG HY ET AL., PHYTOTHERAPY RESEARCH, vol. 26, no. 6, 2012, pages 853 - 9
ABREU CM ET AL., PLOS ONE, vol. 9, no. 5, 2014, pages e97257
ASADA A. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 43, 1998, pages 28392 - 28398
ZHAO XUEYAN ET AL., CHINESE HERBAL MEDICINE, vol. 45, no. 20, 2014, pages 3029 - 3033
WANG HY ET AL., PHYTOTHERAPY RESEARCH, vol. 26, no. 6, 2012, pages 853 - 859
WU TS ET AL., JOURNAL OF NATURAL PRODUCTS, vol. 54, no. 3, 1991, pages 823 - 829
KHIEV PET, ARCHIVES PHARMACAL RESEARCH, vol. 35, no. 9, 2012, pages 1553 - 1558
ROSEN RH ET AL., JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 66, no. 3, 2012, pages 486 - 493
OGBOURNE S. M. ET AL., CANCER RESEARCH, vol. 64, 2004, pages 2833 - 2839
HAMPSON P. ET AL., CANCER IMMUNOL IMMUNOTHER, vol. 57, 2008, pages 1241 - 1251
CHALLACOMBE JM ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 177, 2006, pages 8123 - 8132
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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