Title:
1,4-BENZOXAZINE COMPOUNDS AND DERIVATIVES THEREOF AS THERAPEUTIC DRUGS FOR THE TREATMENT OF NEURODEGENERATIVE CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2010/019911
Kind Code:
A3
Abstract:
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
Inventors:
D MELLO SANTOSH R (US)
BIEHL EDWARD A (US)
BIEHL EDWARD A (US)
Application Number:
PCT/US2009/053932
Publication Date:
May 27, 2010
Filing Date:
August 14, 2009
Export Citation:
Assignee:
UNIV TEXAS (US)
UNIV SOUTHERN METHODIST (US)
D MELLO SANTOSH R (US)
BIEHL EDWARD A (US)
UNIV SOUTHERN METHODIST (US)
D MELLO SANTOSH R (US)
BIEHL EDWARD A (US)
International Classes:
C07D241/40; A61K31/535; A61P21/00; C07D265/36; C07D279/16; C07D319/18; C07D335/04
Domestic Patent References:
| WO2000075139A2 | 2000-12-14 | |||
| WO2008053861A1 | 2008-05-08 |
Foreign References:
| US3865818A | 1975-02-11 |
Other References:
TURK, C.F. ET AL.: "Synthesis and Central Nervous System Activity of 2-arylidene- 4-aminoalkyl-2H-1,4-benzoxazin-3(4H)-ones and Related Compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 5, 1977, pages 729 - 732, XP008144686
See also references of EP 2328877A4
See also references of EP 2328877A4
Attorney, Agent or Firm:
CHALKER, Daniel, J. et al. (Llp2711 Lbj Freeway, Suite 103, Dallas TX, US)
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