Title:
1,4-NAPHTHALENEDIOL AND 1,4-HYDROQUINONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1987001698
Kind Code:
A3
Abstract:
PCT No. PCT/US86/01852 Sec. 371 Date May 18, 1987 Sec. 102(e) Date May 18, 1987 PCT Filed Sep. 5, 1986.Novel 1,4-naphthalenediol and 1,4-hydroquinone derivatives of formulas I, II, III and IV and their therapeutic uses as 5-lipoxygenase inhibitors, leukotriene inhibitors, antiinflammatory and/or inhibitors of mucus secretion agents are described. Also provided are novel intermediates useful for the preparation of said derivatives. I II III IV
Inventors:
BUNDY GORDON L (US)
LIN CHIU-HONG (US)
LIN CHIU-HONG (US)
Application Number:
PCT/US1986/001852
Publication Date:
December 30, 1987
Filing Date:
September 05, 1986
Export Citation:
Assignee:
UPJOHN CO (US)
BUNDY GORDON L (US)
LIN CHIU HONG (US)
BUNDY GORDON L (US)
LIN CHIU HONG (US)
International Classes:
C12N9/99; A61K31/085; A61K31/12; A61K31/195; A61K31/215; A61K31/35; A61K31/351; C07C41/00; C07C43/215; C07C43/23; C07C45/00; C07C46/06; C07C47/277; C07C50/02; C07C50/06; C07C50/10; C07C50/14; C07C50/24; C07C50/28; C07C50/32; C07C50/38; C07C67/00; C07C69/035; C07C69/14; C07C69/353; C07C69/40; C07C227/00; C07C227/18; C07C229/00; C07C229/08; C07D309/00; C07D309/12; C07F7/18; (IPC1-7): C07C101/18; A61K31/085; A61K31/12; A61K31/215; A61K31/35; C07C43/215; C07C43/23; C07C69/14; C07C69/40; C07C175/00; C07D309/12; C07F7/18
Foreign References:
| EP0146348A2 | 1985-06-26 | |||
| EP0201071A2 | 1986-11-12 |
Other References:
CHEMICAL ABSTRACTS, Vol. 52, No. 15, 10 August 1958 (Columbus, Ohio, US) A.N. GRINEV et al.: "Quinones. XXI. Structure of Substances Obtained by Condensation of Toluquinone and alpha-Naphthoquinone with Aceto-Acetic Ester. Ibid. 78-87.", see column 12830b; & Zhur. Obshchei Khim. 28, (1958)
CHEMICAL ABSTRACTS, Vol. 51, No. 5, 10 March 1957 (Columbus, Ohio, US) R. LIVINGSTONE et al.: "Synthesis of Lapachenole", see column 3580h; & J. Chem. Soc. 1956, 3701-4
CHEMICAL ABSTRACTS, Vol. 99, No. 9, 29 August 1983 (Columbus, Ohio, US) K.H. DOETZ et al.: "Reactions of Complexing Ligands. XXIV. Synthesis of Naphthol Derivatives from Carbonylcarbene Complexes and Alkynes: Regioselective Incorporation of the Alkyne to the Naphthalene Framework", see page 644, Abstract No. 70913t, & J. Organomet. Chem. 1983, 247 (2), 187-201 (Ger).
CHEMICAL ABSTRACTS, Vol. 63, No. 10, 8 November 1965 (Columbus, Ohio, US) O. GONCALVES DE LIMA et al.: "Antibiotic Behavior of Compounds Related to the Synthesis of 7-Methoxy-3, 9-Dimethyl-1-Oxaphenalene", see column 13869d; & Rev. Inst. Antibiot., Univ. Recife 5 (1-2), 3-9 (1963) (Port).
Journal of the Chemical Society, Perkin Transactions 1, Organic and Bio-Organic Chemistry, 1983 MITSURU SHIRAISHI et al.: "Quinones. Part 3. Synthesis of Quinone Derivatives having Ethylenic and Acetylenic Bonds: Specific Inhibitors of the Formation of Leukotrienes and 5-Hydroxyicosa-6,8,11,14-Tetraenoic Acid (5-HETE)", pages 1591-1599 cited in the application
CHEMICAL ABSTRACTS, Vol. 51, No. 5, 10 March 1957 (Columbus, Ohio, US) R. LIVINGSTONE et al.: "Synthesis of Lapachenole", see column 3580h; & J. Chem. Soc. 1956, 3701-4
CHEMICAL ABSTRACTS, Vol. 99, No. 9, 29 August 1983 (Columbus, Ohio, US) K.H. DOETZ et al.: "Reactions of Complexing Ligands. XXIV. Synthesis of Naphthol Derivatives from Carbonylcarbene Complexes and Alkynes: Regioselective Incorporation of the Alkyne to the Naphthalene Framework", see page 644, Abstract No. 70913t, & J. Organomet. Chem. 1983, 247 (2), 187-201 (Ger).
CHEMICAL ABSTRACTS, Vol. 63, No. 10, 8 November 1965 (Columbus, Ohio, US) O. GONCALVES DE LIMA et al.: "Antibiotic Behavior of Compounds Related to the Synthesis of 7-Methoxy-3, 9-Dimethyl-1-Oxaphenalene", see column 13869d; & Rev. Inst. Antibiot., Univ. Recife 5 (1-2), 3-9 (1963) (Port).
Journal of the Chemical Society, Perkin Transactions 1, Organic and Bio-Organic Chemistry, 1983 MITSURU SHIRAISHI et al.: "Quinones. Part 3. Synthesis of Quinone Derivatives having Ethylenic and Acetylenic Bonds: Specific Inhibitors of the Formation of Leukotrienes and 5-Hydroxyicosa-6,8,11,14-Tetraenoic Acid (5-HETE)", pages 1591-1599 cited in the application
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