Title:
1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2012/104263
Kind Code:
A3
Abstract:
The present invention relates to 1,4 Oxazines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Inventors:
ANDREINI MATTEO (IT)
GABELLIERI EMANUELE (IT)
NARQUIZIAN ROBERT (FR)
TRAVAGLI MASSIMILIANO (IT)
WOSTL WOLFGANG (DE)
GABELLIERI EMANUELE (IT)
NARQUIZIAN ROBERT (FR)
TRAVAGLI MASSIMILIANO (IT)
WOSTL WOLFGANG (DE)
Application Number:
PCT/EP2012/051481
Publication Date:
September 27, 2012
Filing Date:
January 31, 2012
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
SIENA BIOTECH SPA (IT)
ANDREINI MATTEO (IT)
GABELLIERI EMANUELE (IT)
NARQUIZIAN ROBERT (FR)
TRAVAGLI MASSIMILIANO (IT)
WOSTL WOLFGANG (DE)
SIENA BIOTECH SPA (IT)
ANDREINI MATTEO (IT)
GABELLIERI EMANUELE (IT)
NARQUIZIAN ROBERT (FR)
TRAVAGLI MASSIMILIANO (IT)
WOSTL WOLFGANG (DE)
International Classes:
C07D265/30; A61K31/5377; A61P1/00; A61P3/10; A61P7/02; A61P9/00; A61P19/02; A61P25/28; A61P29/00; A61P35/00; C07D413/10
Domestic Patent References:
| WO2011154431A1 | 2011-12-15 | |||
| WO2011009943A1 | 2011-01-27 | |||
| WO2009103626A1 | 2009-08-27 |
Foreign References:
| EP1942105A1 | 2008-07-09 |
Attorney, Agent or Firm:
MUELLER-AFRAZ, Simona (Grenzacherstrasse 124, Basel, CH)
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