Title:
1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/043956
Kind Code:
A1
Abstract:
Novel 1,4-substituted cyclic amine derivatives which have serotonin antagonism and serve as drugs having high clinical usefulness, especially an agent for the remedy/alleviation/prevention of spastic paralysis or a central muscle relaxant for alleviating myotonia. The derivatives are represented by general formula (I) or pharmacologically acceptable salts thereof, wherein A, B, C, D, T, Y, and Z each represents a methine group or a nitrogen atom; R?1�, R?2�, R?3�, R?4�, and R?5� each represents a substituent; n is an integer of 0 to 3; m is an integer of 0 to 6; and p is an integer of 1 to 3.
Inventors:
KITAZAWA NORITAKA (JP)
UENO KOHSHI (JP)
TAKAHASHI KEIKO (JP)
KIMURA TEIJI (JP)
SASAKI ATSUSHI (JP)
KAWANO KOKI (JP)
OKABE TADASHI (JP)
KOMATSU MAKOTO (JP)
MATSUNAGA MANABU (JP)
KUBOTA ATSUHIKO (JP)
UENO KOHSHI (JP)
TAKAHASHI KEIKO (JP)
KIMURA TEIJI (JP)
SASAKI ATSUSHI (JP)
KAWANO KOKI (JP)
OKABE TADASHI (JP)
KOMATSU MAKOTO (JP)
MATSUNAGA MANABU (JP)
KUBOTA ATSUHIKO (JP)
Application Number:
PCT/JP1998/001481
Publication Date:
October 08, 1998
Filing Date:
March 31, 1998
Export Citation:
Assignee:
EISAI CO LTD (JP)
KITAZAWA NORITAKA (JP)
UENO KOHSHI (JP)
TAKAHASHI KEIKO (JP)
KIMURA TEIJI (JP)
SASAKI ATSUSHI (JP)
KAWANO KOKI (JP)
OKABE TADASHI (JP)
KOMATSU MAKOTO (JP)
MATSUNAGA MANABU (JP)
KUBOTA ATSUHIKO (JP)
KITAZAWA NORITAKA (JP)
UENO KOHSHI (JP)
TAKAHASHI KEIKO (JP)
KIMURA TEIJI (JP)
SASAKI ATSUSHI (JP)
KAWANO KOKI (JP)
OKABE TADASHI (JP)
KOMATSU MAKOTO (JP)
MATSUNAGA MANABU (JP)
KUBOTA ATSUHIKO (JP)
International Classes:
A61K31/135; A61P21/02; C07D211/26; C07D211/74; C07D217/02; C07D217/04; C07D221/04; C07D295/08; C07D295/10; C07D295/18; C07D401/04; C07D401/14; C07D403/04; C07D405/14; C07D417/14; C07D491/04; C07D491/056; C07D513/04; C07D521/00; C07D211/22; (IPC1-7): C07D211/22; C07D217/02; C07D221/04; C07D295/08; C07D295/10; C07D295/12; C07D295/18; C07D401/04; C07D401/14; C07D403/04; C07D405/14; C07D409/14; C07D417/14; C07D471/04; C07D491/056; C07D513/04; A61K31/40; A61K31/435; A61K31/445; A61K31/47; A61K31/495; A61K31/535; A61K31/55
Domestic Patent References:
| WO1996023784A1 | 1996-08-08 | |||
| WO1995033721A1 | 1995-12-14 | |||
| WO1992010192A1 | 1992-06-25 | |||
| WO1997006155A1 | 1997-02-20 | |||
| WO1997047601A1 | 1997-12-18 |
Foreign References:
| EP0470039A2 | 1992-02-05 | |||
| EP0466585A1 | 1992-01-15 |
Other References:
See also references of EP 0976732A4
Attorney, Agent or Firm:
Furuya, Kaoru (1-8-11 Nihonbashi-Horidomech, Chuo-ku Tokyo, JP)
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