Title:
15-DEOXYPROSTAGLANDIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1991/013869
Kind Code:
A1
Abstract:
A 15-deoxyprostaglandin derivative of general formula (I) and an intraocular pressure depressant containing said derivative or a pharmaceutically acceptable salt thereof as the active ingredient . In formula (I), (a) is a five-membered ring selected from among (b), (c), (d), (e), (f); R1 represents hydrogen or lower alkyl; and R2 represents C6 to C12 alkyl, C6 to C12 alkenyl or C6 to C12 alkadienyl, provided that a compound of formula (II) (wherein R' represents H or CH3) is excluded.
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Inventors:
KISHI MORIO (JP)
TAKAHASHI KIMIO (JP)
KAWADA KENJI (JP)
GOH YASUMASA (JP)
TAKAHASHI KIMIO (JP)
KAWADA KENJI (JP)
GOH YASUMASA (JP)
Application Number:
PCT/JP1991/000305
Publication Date:
September 19, 1991
Filing Date:
March 07, 1991
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
A61K31/557; A61P27/06; C07C405/00; (IPC1-7): A61K31/557; C07C405/00
Foreign References:
| US3847962A | 1974-11-12 | |||
| US3872139A | 1975-03-18 | |||
| DE2337581A1 | 1974-03-14 | |||
| JPS5032151A | 1975-03-28 | |||
| JPS5037753A | 1975-04-08 | |||
| JPH02108A | 1990-01-05 | |||
| JPS6366122A | 1988-03-24 | |||
| JPS6147459A | 1986-03-07 | |||
| JPS591418A | 1984-01-06 |
Other References:
CHEMICAL ABSTRACTS, Vol. 64, No. 11, May 23, 1966 (23. 05. 66), Upjohn Co., "Microbiological conversions of unsaturated fatty acids" Refer to Abstract No. 16587f, Belg. 659, 984, Aug. 19, 1965.
CHEMICAL ABSTRACTS, Vol. 64, No. 6, March 14, 1966 (14. 03. 66), Upjohn Co., "Microbiological conversion of unsaturated fatty acids" Refer to Abstract No. 8899d, Belg. 659, 983, Aug. 19, 1965.
CHEMICAL ABSTRACTS, Vol. 64, No. 6, March 14, 1966 (14. 03. 66), Upjohn Co., "Microbiological conversion of unsaturated fatty acids" Refer to Abstract No. 8899d, Belg. 659, 983, Aug. 19, 1965.
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